时间节律学：松果体外与松果体褪黑素节律的昼夜领先关系以及对下丘脑亚日节律的探索
Chronomics: circadian lead of extrapineal vs. pineal melatonin rhythms with an infradian hypothalamic exploration.
作者信息
Zeman M, Józsa R, Cornélissen G, Stebelova K, Bubenik G, Olah A, Poeggeler B, Huether G, Hardeland R, Nagy G, Czernus V, Pan W, Otsuka K, Halberg F
机构信息
Comenius University, Bratislava, Slovakia.
出版信息
Biomed Pharmacother. 2005 Oct;59 Suppl 1:S213-9. doi: 10.1016/s0753-3322(05)80034-4.
A circadian rhythm is documented for plasma, pineal, and hypothalamic melatonin of male and female rats kept on staggered lighting regimens. Log[_10]-transformation of the data usually normalizes, when need be, the distribution of residuals from the 24-hour cosine curve fits. A tentative circadian acrophase chart is presented that shows a lead in circadian acrophase of duodenal over pineal melatonin. The use of antiphasic lighting regimens facilitates circadian studies that can be carried out for several days, thereby allowing the assessment of infradian components such as a circasemiseptan variation in hypothalamic melatonin documented herein. The results are qualified by the presence of a second extremum of a double magnetic storm at the start of mapping.
对于处于交错光照方案下的雄性和雌性大鼠，其血浆、松果体和下丘脑褪黑素的昼夜节律已得到记录。必要时，对数据进行对数[以10为底]转换通常可使24小时余弦曲线拟合残差的分布正常化。给出了一个初步的昼夜节律峰相位图，该图显示十二指肠褪黑素的昼夜节律峰相位领先于松果体褪黑素。使用反相光照方案有助于进行为期数天的昼夜节律研究，从而能够评估诸如本文记录的下丘脑褪黑素的近七日变化等亚日成分。在绘图开始时出现的第二次磁暴极值使结果具有一定局限性。
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