缩短首发精神病未治疗的持续时间——对基线社会功能和生活质量的影响。
Reducing the duration of untreated first-episode psychosis -- effects on baseline social functioning and quality of life.
作者信息
Melle I, Haahr U, Friis S, Hustoft K, Johannessen J O, Larsen T K, Opjordsmoen S, Rund B R, Simonsen E, Vaglum P, McGlashan T
机构信息
Department of Psychiatry, Yale University, New Haven, CT, USA.
出版信息
Acta Psychiatr Scand. 2005 Dec;112(6):469-73. doi: 10.1111/j.1600-0447.2005.00638.x.
OBJECTIVE
Long duration of untreated psychosis (DUP) is associated with poorer outcome. The TIPS study demonstrated that DUP can be reduced through early detection (ED). As quality of life (QoL) is associated with DUP it is expected that reduction of DUP leads to better QoL.
METHOD
Consecutive first-episode patients with a DSM-IV diagnosis of non-organic, non-affective psychosis were included, 281 patients gave informed consent and 263 completed a full evaluation of QoL.
RESULTS
There were no differences in subjective QoL between ED and No-ED groups attributable to reduction in DUP. There were significant bivariate differences in frequency of family and social contacts in favor of the ED group, but multivariate analyses indicated that these differences were based on differences in sample characteristics.
CONCLUSION
Deterioration in QoL may precede overt symptom formation. Focus on functional loss in ED educational campaigns may identify risk subjects earlier in the course of the disorder.
目的
未治疗精神病持续时间（DUP）较长与较差的预后相关。TIPS研究表明，通过早期发现（ED）可缩短DUP。由于生活质量（QoL）与DUP相关，预计缩短DUP会带来更好的生活质量。
方法
纳入连续的首次发作、符合DSM-IV诊断标准的非器质性、非情感性精神病患者，281例患者签署知情同意书，263例完成了生活质量的全面评估。
结果
由于DUP缩短，ED组和非ED组在主观生活质量方面无差异。在家庭和社会接触频率方面，ED组有显著的双变量差异，但多变量分析表明，这些差异基于样本特征的差异。
结论
生活质量恶化可能先于明显症状形成。在ED教育活动中关注功能丧失可能会在疾病过程中更早地识别出风险对象。
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