乙醇脱氢酶（ADH）。同源和异源ADH给药对白化大鼠酒精渴望及肝脏中ADH同工酶活性的影响。
Alcohol dehydrogenase (ADH). Influence of homo- and heterologous ADH administration on albino rats craving for alcohol and on ADH isozyme activity in the liver.
作者信息
Ashmarin I P, Danilova R A, Pshezhetsky A V, Fedorova I M, Obukhova M F, Sagimbaeva Sh K
机构信息
Department of Human and Animal Physiology, School of Biology, Moscow University, Russia.
出版信息
FEBS Lett. 1992 Jul 13;306(1):38-40. doi: 10.1016/0014-5793(92)80832-2.
The effects of homo- and heterologous alcohol dehydrogenase (ADH) administration into albino rats were investigated. It was found that homologous ADH increases and heterologous ADH decreases the craving for ethanol. The latter effect was accompanied by the appearance of anti-ADH-3 antibodies and by a decrease in ADH-3 activity in the liver. Craving for alcohol decreased after both active and passive immunization against ADH.
研究了向白化大鼠体内注射同源和异源乙醇脱氢酶（ADH）的效果。发现同源ADH会增加对白醇的渴望，而异源ADH会降低对白醇的渴望。后一种效应伴随着抗ADH - 3抗体的出现以及肝脏中ADH - 3活性的降低。在对ADH进行主动和被动免疫后，对酒精的渴望均降低。
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