Jenkins Neil E, Mwangi Tabitha W, Kortok Moses, Marsh Kevin, Craig Alister G, Williams Thomas N
Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya.
Clin Infect Dis. 2005 Dec 15;41(12):1817-9. doi: 10.1086/498156. Epub 2005 Nov 8.
An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.
一种细胞间黏附分子-1多态性(ICAM-1(基利菲))在撒哈拉以南非洲地区的出现频率很高,其存在可能会增加患脑型疟疾的易感性。在此,我们报告,与存在野生型细胞间黏附分子-1的儿童相比,ICAM-1(基利菲)纯合子儿童中非疟疾发热的发生率显著更低。我们提出,ICAM-1(基利菲)可能与脓毒症导致的组织损伤和死亡发生率降低有关。