[磷酸盐结合羟基磷灰石多孔支架及其生物相容性的研究]

[Study on hydroxyapatite porous scaffold bonded by phosphates and its biocompatibility].

作者信息

Dong Yinsheng, Zhang Qingguo, Liu Bin, Guo Zongke, Lin Pinghua, Pu Yuepu

机构信息

Department of Mechanical Engineering, Southeast University, Nanjing 210096, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005 Oct;22(5):985-9.

PMID:16294736

Abstract

The porous scaffolds for bone tissue engineering were prepared by foam impregnation. The magnesium and aluminum acid phosphates were used as bonder and the hydroxyapatite ((Ca10 (PO4)6(OH)2, HA) powder as raw materials. Scanning electron microscopy (SEM) examination indicated that the 3D interconnected porous structure of the organic foam was replicated well by the scaffolds calcined at high temperature and the structural requirement of tissue engineering was satisfied. XRD analysis showed that the scaffold was composed of HA and Ca7Mg2P6O24 while calcined at 1150 degrees C for shorter time and of (Ca, Mg)3(PO4)2 when the time prolonged to 2 h. There was no peak of CaO found in the scaffolds by XRD. According to the culture in vitro, the scaffold possesses good biocompatibility and certain degree of degradability.

摘要

采用泡沫浸渍法制备了用于骨组织工程的多孔支架。以镁铝酸磷酸盐为粘结剂，羟基磷灰石（(Ca10 (PO4)6(OH)2, HA）粉末为原料。扫描电子显微镜（SEM）检查表明，高温煅烧后的支架很好地复制了有机泡沫的三维互连多孔结构，满足了组织工程的结构要求。X射线衍射（XRD）分析表明，在1150℃煅烧较短时间时，支架由HA和Ca7Mg2P6O24组成，当煅烧时间延长至2小时时，支架由(Ca, Mg)3(PO4)2组成。XRD分析未在支架中发现CaO峰。体外培养结果表明，该支架具有良好的生物相容性和一定程度的降解性。