Ormel J, Oldehinkel A J, Ferdinand R F, Hartman C A, De Winter A F, Veenstra R, Vollebergh W, Minderaa R B, Buitelaar J K, Verhulst F C
Department of Psychiatry, University Medical Centre, Groningen, The Netherlands.
Psychol Med. 2005 Dec;35(12):1825-35. doi: 10.1017/S0033291705005829.
We investigated the links between familial loading, preadolescent temperament, and internalizing and externalizing problems in adolescence, hereby distinguishing effects on maladjustment in general versus dimension-specific effects on either internalizing or externalizing problems.
In a population-based sample of 2230 preadolescents (10-11 years) familial loading (parental lifetime psychopathology) and offspring temperament were assessed at baseline by parent report, and offspring psychopathology at 2.5-years follow-up by self-report, teacher report and parent report. We used purified measures of temperament and psychopathology and partialled out shared variance between internalizing and externalizing problems.
Familial loading of internalizing psychopathology predicted offspring internalizing but not externalizing problems, whereas familial loading of externalizing psychopathology predicted offspring externalizing but not internalizing problems. Both familial loadings were associated with Frustration, low Effortful Control, and Fear. Frustration acted as a general risk factor predicting severity of maladjustment; low Effortful Control and Fear acted as dimension-specific risk factors that predicted a particular type of psychopathology; whereas Shyness, High-Intensity Pleasure, and Affiliation acted as direction markers that steered the conditional probability of internalizing versus externalizing problems, in the event of maladjustment. Temperament traits mediated one-third of the association between familial loading and psychopathology. Findings were robust across different composite measures of psychopathology, and applied to girls as well as boys.
With regard to familial loading and temperament, it is important to distinguish general risk factors (Frustration) from dimension-specific risk factors (familial loadings, Effortful Control, Fear), and direction markers that act as pathoplastic factors (Shyness, High-Intensity Pleasure, Affiliation) from both types of risk factors. About one-third of familial loading effects on psychopathology in early adolescence are mediated by temperament.
我们研究了家族负荷、青春期前气质与青少年内化和外化问题之间的联系,从而区分对一般适应不良的影响与对内化或外化问题的维度特异性影响。
在一个基于人群的2230名青春期前儿童(10 - 11岁)样本中,通过家长报告在基线时评估家族负荷(父母一生的精神病理学情况)和后代气质,并在2.5年随访时通过自我报告、教师报告和家长报告评估后代精神病理学情况。我们使用了纯化的气质和精神病理学测量方法,并排除了内化和外化问题之间的共同方差。
内化精神病理学的家族负荷预测后代的内化问题而非外化问题,而外化精神病理学的家族负荷预测后代的外化问题而非内化问题。两种家族负荷均与挫折感、低努力控制和恐惧相关。挫折感是预测适应不良严重程度的一般风险因素;低努力控制和恐惧是预测特定类型精神病理学的维度特异性风险因素;而害羞、高强度愉悦和依恋则是在出现适应不良时引导内化与外化问题条件概率的方向标记。气质特征介导了家族负荷与精神病理学之间三分之一的关联。研究结果在不同的精神病理学综合测量中都很稳健,且适用于女孩和男孩。
关于家族负荷和气质,区分一般风险因素(挫折感)与维度特异性风险因素(家族负荷、努力控制、恐惧),以及区分作为病理塑形因素的方向标记(害羞、高强度愉悦、依恋)与这两种风险因素很重要。青春期早期家族负荷对精神病理学的影响约三分之一由气质介导。