Ananth Cande V, Liu Shiliang, Kinzler Wendy L, Kramer Michael S
Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901-1977, USA.
Am J Public Health. 2005 Dec;95(12):2213-7. doi: 10.2105/AJPH.2004.043885.
We examined age, period, and cohort (APC) effects on temporal trends in stillbirths among Black and White women in the United States.
We conducted a cohort study of Black and White women who delivered a singleton live-born or stillborn infant during 1981 through 2000. We analyzed stillbirth rates at 20 or more weeks of gestation within 7 age groups, 4 periods, and 10 "central" birth cohorts after adjusting for confounders.
In both racial groups, women younger than 20 years or 35 years or older were at increased risk of stillbirth; risks decreased over successive periods in all age groups. Birth cohort had no impact on stillbirth trends among Blacks and only a small, nonsignificant effect among Whites. Analyses of various APC combinations showed that Blacks were at a 1.2- to 2.9-fold increased risk for stillbirth relative to Whites. Attributable fractions for stillbirth because of age, period, and cohort effects were 16.5%, 24.9%, and 0.1%, respectively, among Black women and 14.5%, 36.2%, and 2.1%, respectively, among White women.
Strong effects of age and period were observed in stillbirth trends, but these factors do not explain the persistent stillbirth disparity between Black and White women.
我们研究了年龄、时期和队列(APC)对美国黑人和白人女性死产时间趋势的影响。
我们对1981年至2000年期间分娩单胎活产或死产婴儿的黑人和白人女性进行了一项队列研究。在调整混杂因素后,我们分析了7个年龄组、4个时期和10个“核心”出生队列中妊娠20周及以上的死产率。
在两个种族群体中,年龄小于20岁或35岁及以上的女性死产风险增加;所有年龄组的风险在连续时期内均有所下降。出生队列对黑人的死产趋势没有影响,对白人的影响很小且无统计学意义。对各种APC组合的分析表明,黑人的死产风险相对于白人增加了1.2至2.9倍。在黑人女性中,年龄、时期和队列效应导致的死产归因分数分别为16.5%、24.9%和0.1%,在白人女性中分别为14.5%、36.2%和2.1%。
在死产趋势中观察到年龄和时期的强烈影响,但这些因素并不能解释黑人和白人女性之间持续存在的死产差异。