丽江乌头变种根中的三种新二萜生物碱。
Three new diterpene alkaloids from the roots of Aconitum nagarum var. lasiandrum.
作者信息
Zhang Fan, Peng Shu-Lin, Liao Xun, Yu Kai-Bai, Ding Li-Sheng
机构信息
Chengdu Institute of Biology, Chinese Academy of Sciences, PR China.
出版信息
Planta Med. 2005 Nov;71(11):1073-6. doi: 10.1055/s-2005-873135.
Three new diterpene alkaloids, 16,17-dihydro-12 beta,16 beta-epoxynapelline (1), N-deethyl- N-methyl-12-epi-napelline (2) and 11- epi-16 alpha,17-dihydroxylepenine (3), along with twenty-six known alkaloids (4 - 29) were isolated from the roots of Aconitum nagarum var. lasiandrum. The chemical structures of the new compounds were established by HR-MS as well as 1D- and 2D-NMR spectroscopic analysis. The absolute stereochemistry of 1 was confirmed by X-ray crystallography.
从滇南乌头的根中分离出三种新的二萜生物碱，16,17-二氢-12β,16β-环氧那坡林（1）、N-去乙基-N-甲基-12-表那坡林（2）和11-表-16α,17-二羟基勒平宁（3），以及26种已知生物碱（4 - 29）。通过高分辨质谱（HR-MS）以及一维和二维核磁共振光谱分析确定了新化合物的化学结构。通过X射线晶体学确定了1的绝对立体化学结构。
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