Salihu Hamisu M, Mbuba Caroline K, Oluwatade Olatunji J, Aliyu Muktar H
Department of Maternal and Child Health, University of Alabama, Birmingham, UK.
Matern Child Health J. 2005 Sep;9(3):229-35. doi: 10.1007/s10995-005-0011-9.
The objective of this study is to determine the association between unmarried status and infant mortality among twins born to teenagers.
We conducted a retrospective cohort study on twin live births to teenagers in the United States from 1995 through 1998 using the Vital Records assembled by the National Center for Health Statistics. We compared mortality estimates among twins of single to those of married mothers using the generalized estimating equation framework, which also adjusted for intracluster correlations.
Analysis involved 28592 individual twins of teenager mothers, with both cluster members being live-born. Out of these, 21.8% (n = 6238) were born to married and 78.2% (n = 22,354) to single mothers. Infant and postneonatal mortality was 17% and 36% higher among twins of single teenager mothers (odds ratio (OR) = 1.17; 95% confidence interval (CI) = 1.01-1.40) and (OR = 1.36; 95% CI = 1.01-1.87), respectively. However, neonatal mortality was comparable (OR = 1.12; 95% CI = 0.92-1.34). Twins of single mothers were also more likely to be of low birth weight, very low birth weight, preterm and very preterm (p < 0.0001) but had the same risk level for smallness for gestational age as compared to twins of married teenagers.
Single motherhood was associated with increased infant mortality among twins born to teenagers. The critical time of elevated risk was the postneonatal period and the survival disadvantage of twins of single mothers was as a result of the higher-than-expected level of preterm rather than small for gestational age births. These findings have potential clinical and public health relevance.
本研究旨在确定青少年生育的双胞胎中未婚状态与婴儿死亡率之间的关联。
我们利用美国国家卫生统计中心汇编的生命记录,对1995年至1998年在美国青少年生育的双胞胎活产情况进行了一项回顾性队列研究。我们使用广义估计方程框架比较了单身母亲和已婚母亲所生双胞胎的死亡率估计值,该框架还对聚类内相关性进行了调整。
分析涉及28592名青少年母亲的个体双胞胎,两个聚类成员均为活产。其中,21.8%(n = 6238)为已婚母亲所生,78.2%(n = 22354)为单身母亲所生。单身青少年母亲所生双胞胎的婴儿死亡率和新生儿后期死亡率分别高出17%和36%(优势比(OR)= 1.17;95%置信区间(CI)= 1.01 - 1.40)和(OR = 1.36;95% CI = 1.01 - 1.87)。然而,新生儿死亡率相当(OR = 1.12;95% CI = 0.92 - 1.34)。单身母亲所生双胞胎也更有可能出生时体重低、极低体重、早产和极早产(p < 0.0001),但与已婚青少年所生双胞胎相比,其小于胎龄的风险水平相同。
青少年生育的双胞胎中,单身母亲与婴儿死亡率增加有关。风险升高的关键时期是新生儿后期,单身母亲所生双胞胎的生存劣势是由于早产水平高于预期而非小于胎龄出生。这些发现具有潜在的临床和公共卫生意义。