Jesri Ammar, Okonofua Eni C, Egan Brent M
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
J Clin Hypertens (Greenwich). 2005 Dec;7(12):705-11; quiz 712-3. doi: 10.1111/j.1524-6175.2005.04809.x.
Platelet and white blood cell counts are higher among some insulin-resistant patients and may contribute to atherothromboembolic complications. Metabolic syndrome patients are insulin resistant, often hypertensive, and at high cardiovascular disease risk, yet the relationship of platelets to the metabolic syndrome is unknown. Platelet and white blood cell counts were obtained from 135 volunteers who had measurements of blood pressure, fasting triglycerides, high-density lipoprotein cholesterol, and glucose. A body mass index >30 kg/m2 served as a surrogate for increased waist circumference. Subjects were subdivided into three groups by the number of metabolic syndrome criteria, i.e., no metabolic syndrome risk factor (MS-0; n = 40), one or two metabolic syndrome risk factors (MS1-2; n = 61), and three to five metabolic syndrome risk factors (MS3-5; n = 34). Platelet counts were increased significantly from 226+/-8 to 257+/-8 and 276+/-10 (x10(3)/mm3) in the MS-0, MS1-2, and MS3-5 groups, respectively (p < 0.01), after adjustment for age, gender, ethnicity, total cholesterol, and low-density lipoprotein cholesterol. White blood cell counts were also increased across the three groups (5.4+/-0.2, 6.2+/-0.2, and 6.6+/-0.3 [x10(3)/mm3]; p < 0.01) after multivariate adjustment. Compared with patients with zero to two metabolic syndrome risk factors, metabolic syndrome patients have higher platelet and white blood counts, which may serve as markers of a prothrombotic and proinflammatory state and contributors to atherothromboembolic risk.
在一些胰岛素抵抗患者中，血小板和白细胞计数较高，这可能会导致动脉粥样血栓栓塞并发症。代谢综合征患者存在胰岛素抵抗，常伴有高血压，心血管疾病风险较高，但血小板与代谢综合征之间的关系尚不清楚。从135名志愿者身上获取了血小板和白细胞计数，这些志愿者还测量了血压、空腹甘油三酯、高密度脂蛋白胆固醇和血糖。体重指数>30kg/m²作为腰围增加的替代指标。根据代谢综合征标准的数量将受试者分为三组，即无代谢综合征风险因素（MS-0；n = 40）、有一或两个代谢综合征风险因素（MS1-2；n = 61）以及有三至五个代谢综合征风险因素（MS3-5；n = 34）。在对年龄、性别、种族、总胆固醇和低密度脂蛋白胆固醇进行校正后，MS-0、MS1-2和MS3-5组的血小板计数分别从226±8显著增加至257±8和276±10（××10³/mm³）（p < 0.01）。多因素校正后，三组的白细胞计数也有所增加（分别为5.4±0.2、6.2±0.2和6.6±0.3 [××10³/mm³]；p < 0.01）。与有零至两个代谢综合征风险因素的患者相比，代谢综合征患者的血小板和白细胞计数更高，这可能是促血栓形成和促炎状态的标志物，并增加动脉粥样血栓栓塞风险。
