某些局部用耳科溶液的抗菌活性评估
Assessment of antibacterial activity of some topical otological solutions.
作者信息
Uçüncü Harun, Aktaş A Esin, Yazgi Halil, Yiğit Nimet, Aktan Bülent, Sütbeyaz Yavuz
机构信息
Department of Otolaryngology, Medicine Faculty of Atatürk University, Erzurum, Turkey.
出版信息
Kulak Burun Bogaz Ihtis Derg. 2005;14(5-6):97-100.
OBJECTIVES
Otological solutions have long been used in the treatment of the bacterial and fungal infections of the ear. We investigated antibacterial activity of some otic solutions against the most common bacteria isolated from discharging ears.
STUDY DESIGN
Three solutions were used (Castellani's, Burrow's, and 2% salicyl alcohol) for 20 fresh isolates of each of the following organisms: Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter spp.. The activity of each solution was determined by the size of the zone of inhibition of bacterial growth.
RESULTS
The Castellani's solution showed significantly larger average inhibition zones than the other solutions did (p<0.001).
CONCLUSION
The Castellani's solution may be considered a good option against bacterial or mixed infections (bacterial and fungal) of the ear.
目的
耳科溶液长期以来一直用于治疗耳部的细菌和真菌感染。我们研究了一些耳科溶液对从流脓耳部分离出的最常见细菌的抗菌活性。
研究设计
使用三种溶液（ Castellani溶液、Burrow溶液和2%水杨酸酒精），对以下每种微生物的20个新鲜分离株进行实验：金黄色葡萄球菌、奇异变形杆菌、铜绿假单胞菌、大肠杆菌和肠杆菌属。每种溶液的活性通过细菌生长抑制圈的大小来确定。
结果
Castellani溶液显示出比其他溶液明显更大的平均抑制圈（p<0.001）。
结论
Castellani溶液可被视为治疗耳部细菌感染或混合感染（细菌和真菌）的良好选择。
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