Liu Haihong, Liu Zhening, Liang Meng, Hao Yihui, Tan Lihua, Kuang Fan, Yi Yanhong, Xu Lin, Jiang Tianzi
Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Neuroreport. 2006 Jan 23;17(1):19-22. doi: 10.1097/01.wnr.0000195666.22714.35.
We used a newly reported regional homogeneity approach to measure the temporal homogeneity of blood oxygen level-dependent signal for exploring the brain activity of schizophrenia in a resting state. The results showed decreased regional homogeneity in schizophrenia, which distributed over the bilateral frontal, temporal, occipital, cerebellar posterior, right parietal and left limbic lobes, similar to the findings reported in previous resting state functional studies. The brain regions that showed decreased regional homogeneity are believed to be involved in the psychopathology and pathophysiology of schizophrenia. Our results indicate that abnormal brain activity of schizophrenia may exist in a resting state and the regional homogeneity may be potentially helpful in understanding the resting state of schizophrenia.
我们采用一种新报道的局部一致性方法来测量血氧水平依赖信号的时间一致性，以探索精神分裂症患者静息状态下的脑活动。结果显示，精神分裂症患者的局部一致性降低，分布于双侧额叶、颞叶、枕叶、小脑后部、右侧顶叶和左侧边缘叶，这与先前静息态功能研究的报道结果相似。局部一致性降低的脑区被认为与精神分裂症的精神病理学和病理生理学有关。我们的结果表明，精神分裂症患者在静息状态下可能存在脑活动异常，局部一致性可能有助于理解精神分裂症的静息状态。
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