Giugliano Dario, Esposito Katherine
Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Centre, Second University of Naples, Naples, Italy.
Ann N Y Acad Sci. 2005 Nov;1056:253-60. doi: 10.1196/annals.1352.012.
Diets that are high in fruits, vegetables, legumes, and whole grains and include fish, nuts, and low-fat dairy products have protective health effects. The traditional Mediterranean diet encompasses these dietary characteristics. Other compounds of the Mediterranean diet, the antioxidants, which exist in abundance in vegetables, fruit, beverages, and also virgin olive oil, may contribute to the prevention of coronary heart disease and possibly several forms of cancer and other diseases, thus providing a plausible explanation for its apparent benefits. It may be misleading to focus on a single element of the diet; this may explain, at least in part, the disappointing and frustrating results obtained in trials with vitamin supplementation, prematurely thought to be "the magic bullet" for preventing a myriad of chronic diseases. The results of intervention studies aimed at evaluating whether Mediterranean-type diets are superior to classic diets in the secondary prevention of coronary heart disease have all been encouraging. The biologic mechanisms by which these compounds might exert their effects include, among others, antioxidant functions and induction of detoxification enzymes. However, from a public health perspective it is not essential to wait for elucidation of every mechanism underlying health promotion activities and interventions; given the simplicity of the diet quality score, increasing the intake of recommended foods represents a practical recommendation for improving health.
富含水果、蔬菜、豆类和全谷物且包含鱼类、坚果和低脂乳制品的饮食对健康具有保护作用。传统的地中海饮食就具备这些饮食特点。地中海饮食中的其他成分,即存在于蔬菜、水果、饮品以及初榨橄榄油中的大量抗氧化剂,可能有助于预防冠心病以及多种形式的癌症和其他疾病,从而为其显著益处提供了合理的解释。仅关注饮食中的单一元素可能会产生误导;这至少可以部分解释在维生素补充试验中所得到的令人失望和沮丧的结果,这些试验曾过早地认为维生素是预防众多慢性疾病的“神奇子弹”。旨在评估地中海式饮食在冠心病二级预防方面是否优于传统饮食的干预研究结果均令人鼓舞。这些化合物发挥作用的生物学机制包括抗氧化功能和诱导解毒酶等。然而,从公共卫生的角度来看,并不一定要等到弄清楚促进健康活动和干预措施背后的每一种机制;鉴于饮食质量评分的简单性,增加推荐食物的摄入量是改善健康的一项切实可行的建议。