黑曲霉中膜蛋白过量表达菌株中伴侣蛋白编码基因bipA的HacA非依赖性诱导
HacA-independent induction of chaperone-encoding gene bipA in Aspergillus niger strains overproducing membrane proteins.
作者信息
Davé Anoushka, Jeenes David J, Mackenzie Donald A, Archer David B
机构信息
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
出版信息
Appl Environ Microbiol. 2006 Jan;72(1):953-5. doi: 10.1128/AEM.72.1.953-955.2006.
Abstract
Transcription of two unfolded protein response genes, hacA and bipA, was examined in Aspergillus niger strains overproducing membrane proteins. Despite elevated bipA mRNA levels, no 5'-truncated hacA transcript was detected, raising the possibility of a hacA-independent induction of bipA mRNA under the stress of membrane protein overproduction in A. niger.
摘要
在过量生产膜蛋白的黑曲霉菌株中，检测了两个未折叠蛋白反应基因hacA和bipA的转录情况。尽管bipA mRNA水平升高，但未检测到5'-截短的hacA转录本，这增加了在黑曲霉膜蛋白过量生产应激下bipA mRNA的诱导不依赖于hacA的可能性。
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