Chen Zhi-qiang, Yang Wen-jun, Cai Lei
Department of Radiology, the Affiliated Hospital of Ningxia Medical College, Yinchuan 750004, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Dec;23(6):438-41.
To investigate clinical and imaging characteristics of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and their relationship to the prognosis.
The clinical, CT and MRI findings in 46 patients with DEACMP were analysed and compared.
The main manifestations of the disease were mental and extrapyramidal impairment. CT scan showed diffuse low density changes in bilateral cerebral white matter, bilateral or unilateral globus pallidus or basal ganglia areas. The MRI showed necrosis and degeneration of glodus pallidus and cerebral white matter demyelination mainly around the ventricles, with high signal intensity in T(2)-weighted and equal or low signal intensity in T(1)-weighted as well as the lesions in hippocampus and brain stem. There was the sign of encephalatrophy in the late stage. The positive detectable rate of MRI was 82.1%, higher than that of CT, 43.2%. MRI was more sensitive than CT.
The prognosis of the patients is closely related with the age, time of come after DEACMP and the effectiveness of treatment. Both CT and MRI are valuable in the diagnosis and evaluation of the prognosis for DEACMP. MRI is more sensitive than CT in the diagnosis of DEACMP.
探讨急性一氧化碳中毒后迟发性脑病（DEACMP）的临床及影像学特点及其与预后的关系。
对46例DEACMP患者的临床、CT及MRI表现进行分析比较。
该病主要表现为精神及锥体外系损害。CT扫描显示双侧脑白质、双侧或单侧苍白球或基底节区弥漫性低密度改变。MRI显示苍白球坏死、变性，脑室周围脑白质脱髓鞘，T2加权像呈高信号，T1加权像呈等或低信号，海马及脑干也有病灶。晚期有脑萎缩征象。MRI阳性检出率为82.1%，高于CT的43.2%。MRI比CT更敏感。
患者预后与年龄、DEACMP后就诊时间及治疗效果密切相关。CT和MRI对DEACMP的诊断及预后评估均有价值。MRI在DEACMP诊断中比CT更敏感。
