非对映选择性阳离子串联环化反应构建氮杂环骨架：(-)-地西贝碱PP的全合成

Diastereoselective cationic tandem cyclizations to N-heterocyclic scaffolds: total synthesis of (-)-dysibetaine PP.

作者信息

Ijzendoorn Denis R, Botman Peter N M, Blaauw Richard H

机构信息

Chiralix BV, Nijmegen, The Netherlands.

出版信息

Org Lett. 2006 Jan 19;8(2):239-42. doi: 10.1021/ol052598r.

DOI:10.1021/ol052598r

PMID:16408884

Abstract

[reaction: see text] Herein, we report a short and diastereoselective synthesis of the natural product (-)-dysibetaine PP. The key step in the synthetic sequence is a novel highly diastereoselective tandem-cyclization reaction of an enantiomerically pure dipeptide. This cyclization methodology is applied in the synthesis of a broader range of N-heterocyclic scaffolds.

摘要

[反应：见正文] 在此，我们报道了天然产物（-）- dysibetaine PP的一种简短且非对映选择性的合成方法。合成序列中的关键步骤是一种对映体纯二肽的新型高度非对映选择性串联环化反应。这种环化方法应用于更广泛的N-杂环骨架的合成。