来自北美枫香球果的羽扇豆烷型和齐墩果烷型三萜类化合物。

Lupane and oleanane triterpenoids from the cones of Liquidamber styraciflua.

作者信息

Fukuda Yuko, Yamada Takeshi, Wada Shun-ich, Sakai Kuniyoshi, Matsunaga Shunyo, Tanaka Reiko

机构信息

Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

出版信息

J Nat Prod. 2006 Jan;69(1):142-4. doi: 10.1021/np0581014.

DOI:10.1021/np0581014

PMID:16441087

Abstract

A new lupane- (1) and a new oleanane-type (2) triterpenoid, together with a known compound, massagenic acid G, were isolated from the cones of Liquidamber styraciflua. The structures of 1 and 2 were determined as 6beta,30-dihydroxy-3-oxolup-20(29)-en-28-oic acid and 3alpha-hydroxy-11-oxoolean-12-en-28-oic acid, respectively, on the basis of spectroscopic methods and chemical conversion. Compound 1 and several structural analogues were evaluated for cytotoxicity against the P388 (murine lymphocyte leukemia) and the A549 (human lung cancer) cell lines.

摘要

从北美枫香树的球果中分离出一种新的羽扇豆烷型（1）和一种新的齐墩果烷型（2）三萜类化合物，以及一种已知化合物——致幻酸G。基于光谱方法和化学转化，分别确定了1和2的结构为6β,30 - 二羟基 - 3 - 氧代羽扇 - 20(29) - 烯 - 28 - 酸和3α - 羟基 - 11 - 氧代齐墩果 - 12 - 烯 - 28 - 酸。对化合物1和几种结构类似物进行了针对P388（小鼠淋巴细胞白血病）和A549（人肺癌）细胞系的细胞毒性评估。