Rolle Axel, Pereszlenyi Arpad, Koch Rainer, Bis Beata, Baier Barbara
Department of Thoracic and Vascular Surgery, Centre of Pneumology and Thoracic Surgery, Coswig Specialised Hospital, D-01640 Coswig/Dresden, Germany.
Lasers Surg Med. 2006 Jan;38(1):26-32. doi: 10.1002/lsm.20259.
Advantages of a new 1,318 nm Nd:YAG laser based on multiple lung metastasectomies are shown.
STUDY DESIGN/MATERIALS AND METHODS: Ninety-three percent of 328 patients with metastases (8/patient, range 1-124) had precision laser resections (lobectomy-rate reduced to 7%); this laser delivers 20 kW/cm(2) 1,318 nm power densities with 400 microm fibers, and a focussing handpiece. Absorption in water is tenfold higher.
Between 1/1996 and 12/2003 in 328 patients (164 males/females, 61 years) 3,267 nodules were removed. Pathologic examination revealed 2,546 metastases (range 3-80 mm) from kidney (n = 112), colorectal (n = 91), and breast cancers (n = 35). In 85% of patients where the complete resection was achieved the 5-year survival was 41%. For remaining 15% (incomplete resection) the 5-year survival was 7%. Five-year survival for patients with 10 (and more) metastases was 28%, for patients with 20 (and more) was 26%. No 30-day mortality was observed.
This new laser system facilitates any kind of parenchymal lung resection in lobe-sparing manner and in case of complete resection improves significantly the survival.
展示了一种基于多次肺转移瘤切除术的新型1318纳米钕钇铝石榴石激光的优势。
研究设计/材料与方法:328例有转移瘤的患者(平均每位患者8个转移瘤,范围为1至124个)中,93%接受了精确激光切除术(肺叶切除率降至7%);该激光通过400微米的光纤和聚焦手持器械可提供20千瓦/平方厘米的1318纳米功率密度。在水中的吸收率高出十倍。
在1996年1月至2003年12月期间,328例患者(164例男性/女性,平均年龄61岁)共切除了3267个结节。病理检查发现2546个转移瘤(范围为3至80毫米),原发肿瘤分别为肾癌(n = 112)、结直肠癌(n = 91)和乳腺癌(n = 35)。在85%实现完全切除的患者中,5年生存率为41%。其余15%(不完全切除)的患者5年生存率为7%。有10个(及以上)转移瘤的患者5年生存率为28%,有20个(及以上)转移瘤的患者5年生存率为26%。未观察到30天死亡率。
这种新型激光系统有助于以保留肺叶的方式进行任何类型的实质性肺切除术,并且在完全切除的情况下可显著提高生存率。