2.1兆帕和4.1兆帕过氧化氢暴露对小鼠听性脑干诱发电位的影响。
Effect of 2.1 MPa and 4.1 MPa H2O2 exposure on auditory brain stem evoked potential in mice.
作者信息
Weibing X, Jun L, Zheng M, Fengtao Y, Hexiang Z
机构信息
The Diving Medicine Laboratory, the NMRI of the PLA Shanghai, China.
出版信息
Undersea Hyperb Med. 2005 Sep-Oct;32(5):391-6.
Brain auditory evoked potential (BAEP) in mice exposed to hyperbaric H2O2 pressure was monitored to reveal the correlation between altered synaptic transmission and hydrogen narcosis or isobaric HPNS. Inter peak latencies and wave amplitudes were selected as indices of assessment. The animals were exposed either to He-O2 or H2-O2 at 2.1 MPa and 4.1 MPa. Results showed that synaptic transmission was inhibited to various extents. The inhibition was partly due to the narcotic effect of hydrogen, which was added to the effect caused by hydrostatic pressure. On the other hand, asymmetrical reaction of each segment in the neuro-network might be responsible for the occurrence of HPNS.
监测暴露于高压过氧化氢环境下小鼠的脑听觉诱发电位（BAEP），以揭示突触传递改变与氢麻醉或等压高气压神经综合征（HPNS）之间的相关性。选择峰间潜伏期和波幅作为评估指标。将动物置于2.1兆帕和4.1兆帕的氦氧或氢氧环境中。结果表明，突触传递受到不同程度的抑制。这种抑制部分归因于氢气的麻醉作用，它叠加了静水压力所产生的影响。另一方面，神经网络中各节段的不对称反应可能是HPNS发生的原因。
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