Deckersbach Thilo, Miller Karen K, Klibanski Anne, Fischman Alan, Dougherty Darin D, Blais Mark A, Herzog David B, Rauch Scott L
Department of Psychiatry, Massachusetts General Hospital, Boston, USA.
Depress Anxiety. 2006;23(3):133-8. doi: 10.1002/da.20152.
Factor-analytic approaches to human personality have consistently identified several core personality traits, such as Extraversion/Introversion, Neuroticism, Agreeableness, Consciousness, and Openness. There is an increasing recognition that certain personality traits may render individuals vulnerable to psychiatric disorders, including anxiety disorders and depression. Our purpose in this study was to explore correlates between the personality dimensions neuroticism and extraversion as assessed by the NEO Five-Factor Inventory (NEO-FFI) and resting regional cerebral glucose metabolism (rCMRglu) in healthy control subjects. Based on the anxiety and depression literatures, we predicted correlations with a network of brain structures, including ventral and medial prefrontal cortex (encompassing anterior cingulate cortex and orbitofrontal cortex), insular cortex, anterior temporal pole, ventral striatum, and the amygdala. Twenty healthy women completed an (18F)FDG (18F-fluorodeoxyglucose) positron emission tomography (PET) scan at rest and the NEO-FFI inventory. We investigated correlations between scores on NEO-FFI Neuroticism and Extraversion and rCMRglu using statistical parametric mapping (SPM99). Within a priori search territories, we found significant negative correlations between Neuroticism and rCMRglu in the insular cortex and positive correlations between Extraversion and rCMRglu in the orbitofrontal cortex. No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively.
对人类人格的因素分析方法一直都能确定几个核心人格特质，比如外向性/内向性、神经质、宜人性、尽责性和开放性。人们越来越认识到某些人格特质可能会使个体易患精神疾病，包括焦虑症和抑郁症。我们这项研究的目的是在健康对照受试者中，探索通过NEO五因素问卷（NEO-FFI）评估的神经质和外向性这两个人格维度与静息状态下局部脑葡萄糖代谢（rCMRglu）之间的相关性。基于焦虑和抑郁方面的文献，我们预测其与包括腹侧和内侧前额叶皮质（包括前扣带回皮质和眶额皮质）、岛叶皮质、颞极前部、腹侧纹状体和杏仁核在内的一个脑结构网络存在相关性。20名健康女性在静息状态下完成了一次（18F）FDG（18F-氟脱氧葡萄糖）正电子发射断层扫描（PET）以及NEO-FFI问卷。我们使用统计参数映射（SPM99）研究了NEO-FFI神经质和外向性得分与rCMRglu之间的相关性。在预先设定的搜索区域内，我们发现神经质与岛叶皮质的rCMRglu之间存在显著负相关，外向性与眶额皮质的rCMRglu之间存在显著正相关。在前扣带回、杏仁核或腹侧纹状体方面未发现显著相关性。神经质和外向性分别与岛叶皮质和眶额皮质的活动有关。
