用喷他佐辛或SFK 10047进行长期治疗可降低大鼠纹状体和伏隔核中脑啡肽原mRNA的水平。

Chronic treatment with pentazocine or SFK 10047 decrease proenkephalin mRNA levels in the rat striatum and nucleus accumbens.

作者信息

Angulo J A, Ledoux M, McEwen B S

机构信息

Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.

出版信息

Neurosci Lett. 1991 Jan 14;122(1):47-9. doi: 10.1016/0304-3940(91)90189-z.

DOI:10.1016/0304-3940(91)90189-z

PMID:1647506

Abstract

In order to assess the effect of sigma (sigma) receptor activity on striatal and limbic enkephalinergic cells we measured proenkephalin mRNA levels by in situ hybridization histochemistry after chronic treatment with the sigma-receptor agonist drugs SKF 10047 or pentazocine. Chronic treatment with SKF 10047 decreased proenkephalin mRNA levels in the anterior aspect of the caudate-putamen (CPU) and the nucleus accumbens by 20-22% relative to controls. No significant effect was observed in the medial aspect of the CPU. Treatment with pentazocine decreased proenkephalin mRNA levels by 20-25% in all 3 brain regions. The results demonstrate that sigma-receptor activity can exert tonic effects on proenkephalin mRNA expression in the striatum and the nucleus accumbens of the rat.

摘要

为了评估西格玛（σ）受体活性对纹状体和边缘脑区脑啡肽能细胞的影响，我们在用σ受体激动剂药物SKF 10047或喷他佐辛进行慢性处理后，通过原位杂交组织化学法测量了前脑啡肽原mRNA水平。相对于对照组，用SKF 10047进行慢性处理使尾壳核（CPU）前部和伏隔核中的前脑啡肽原mRNA水平降低了20 - 22%。在CPU内侧未观察到显著影响。用喷他佐辛处理使所有3个脑区的前脑啡肽原mRNA水平降低了20 - 25%。结果表明，σ受体活性可对大鼠纹状体和伏隔核中的前脑啡肽原mRNA表达产生紧张性作用。