Phototoxic activity of a thiophene polyacetylene from Leuzea carthamoides.

作者信息

Chobot Vladimír, Vytlacilová Jitka, Kubicová Lenka, Opletal Lubomír, Jahodár Ludek, Laakso Into, Vuorela Pia

机构信息

Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

出版信息

Fitoterapia. 2006 Apr;77(3):194-8. doi: 10.1016/j.fitote.2006.01.001. Epub 2006 Feb 20.

DOI:10.1016/j.fitote.2006.01.001

PMID:16488556

Abstract

The thiophene polyacetylene (E)-1-[5-(hept-5-en-1,3-diynyl)-2-thienyl]ethan-1,2-diol, isolated from the roots of Leuzea carthamoides, showed phototoxic activity in the assay systems of histidine photo-oxidation, Artemia and Tubifex assays. The effects were compared with the standard photosensitizer xanthotoxin.

摘要