一种来自家蚕前胸腺的新型受体cDNA。

A novel type of receptor cDNA from the prothoracic glands of the silkworm, Bombyx mori.

作者信息

Nagata Shinji, Namiki Toshiki, Ko Rinkei, Kataoka Hiroshi, Suzuki Akinori

机构信息

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.

出版信息

Biosci Biotechnol Biochem. 2006 Feb;70(2):554-8. doi: 10.1271/bbb.70.554.

DOI:10.1271/bbb.70.554

PMID:16495681

Abstract

A cDNA encoding a novel heptahelical receptor from the prothoracic glands of the silkworm, Bombyx mori was cloned and sequenced during screening of a prothoracicotropic hormone (PTTH) receptor. Orthologs of this receptor are found not only in insects, but also in the vertebrates. In B. mori, ubiquitous expression of the mRNA was observed in the larva. Also, a higher expression level in the prothoracic glands was observed before molting and metamorphosis and was impaired after pupal molting. But, further analysis is required to confirm whether this receptor cDNA encodes the PTTH receptor.

摘要

在筛选促前胸腺激素（PTTH）受体的过程中，克隆并测序了一种来自家蚕前胸腺的编码新型七螺旋受体的cDNA。该受体的直系同源物不仅存在于昆虫中，也存在于脊椎动物中。在家蚕中，观察到该mRNA在幼虫中普遍表达。此外，在蜕皮和变态前，前胸腺中的表达水平较高，而在蛹期蜕皮后则受到损害。但是，需要进一步分析以确认该受体cDNA是否编码PTTH受体。