Huppertz H I, Niki N P, Chantler J K
Division of Medical Microbiology, University of British Columbia, Vancouver, Canada.
J Rheumatol. 1991 May;18(5):699-704.
A model system has been developed to investigate the comparative ability of different viruses to replicate and persist intraarticularly. The viruses chosen for study were rubella, mumps, Coxsackie B4, adenovirus and varicella zoster, a selection of viruses with different degrees of association with joint symptoms in clinical studies. Our results showed that these viruses demonstrated a range of abilities to infect and persist in human joint tissue cultured in vitro. The most arthritogenic viruses, rubella, and to a lesser extent mumps, replicated and penetrated deeply into the synovial membrane. In contrast, the other 3 viruses were much less arthrotropic, and may only induce arthritis by immunopathological mechanisms.
已开发出一种模型系统，用于研究不同病毒在关节内复制和持续存在的比较能力。选择用于研究的病毒有风疹病毒、腮腺炎病毒、柯萨奇B4病毒、腺病毒和水痘带状疱疹病毒，这些病毒在临床研究中与关节症状有不同程度的关联。我们的结果表明，这些病毒在体外培养的人关节组织中表现出一系列感染和持续存在的能力。最具关节炎致病性的病毒风疹病毒，以及程度稍轻的腮腺炎病毒，能够复制并深入渗透到滑膜中。相比之下，其他三种病毒的亲关节性要低得多，可能仅通过免疫病理机制诱发关节炎。
