Chikviladze D P, Sindzhikashvili M N, Metreveli D A, Mikeladze M L, Gachechiladze Kh E
Georgian Med News. 2006 Jan(130):122-5.
Serotyping of 565 E.coli strains isolated from 273 patients with ulcerative colitis (70 patients); chronic catarrhal colitis (96 patients), adaptive colitis (107 patient) and of 72 E. coli strains isolated from 50 practically healthy persons (control group) was performed. Serotyping was performed in reaction of agglutination, on stage-glass, by use of commercial set consisting of O and H monovalent serum. As a result of performed investigation it was determined, that in patients with different intestinal inflammatory pathologies, there were found significant pathologic changes in intestinal microbiocenosis, in which main role are playing by strains of E. coli. Such violations of intestinal microbiocenosis often are leading to complications of basic disease. Serotyping of E. coli strains has shown, that in formation of pathologic microbiocenosis with more or less equal frequency are taking part enteropathogenic, enteroinvasive, enterotoxic strains of E. coli and also some definite serotypes of E. coli - representatives of normal intestinal microflora with ability of synthesis of thermolabile enterotoxin.
对从273例溃疡性结肠炎患者(70例)、慢性卡他性结肠炎患者(96例)、适应性结肠炎患者(107例)分离出的565株大肠杆菌以及从50名健康人(对照组)分离出的72株大肠杆菌进行了血清分型。血清分型采用玻片凝集反应,使用由O和H单价血清组成的商业试剂盒进行。调查结果表明,在患有不同肠道炎症性疾病的患者中,肠道微生物群落存在显著的病理变化,其中大肠杆菌菌株起主要作用。这种肠道微生物群落的紊乱常常导致基础疾病的并发症。大肠杆菌菌株的血清分型表明,致病性、侵袭性、产毒性大肠杆菌菌株以及一些特定血清型的大肠杆菌(具有合成不耐热肠毒素能力的正常肠道微生物群代表)以大致相同的频率参与病理性微生物群落的形成。