Koufman Jamie A, Rees Catherine J, Halum Stacey L, Blalock David
Center for Voice and Swallowing Disorders, Dept of Otolaryngology, Wake Forest University-Baptist Medical Center, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Ann Otol Rhinol Laryngol. 2006 Feb;115(2):97-102. doi: 10.1177/000348940611500203.
Despite the belief that it represents a central neurologic dysfunctional process, adductor-type spasmodic dysphonia without tremor is usually effectively treated by injection of botulinum toxin A; however, in most cases such injections must be repeated every few months. A promising new surgical procedure is herein reported.
Under local anesthesia with intravenous sedation, a large laryngoplasty window is created, and under direct vision with intraoperative voice monitoring, fibers from the thyroarytenoid and lateral cricoarytenoid muscles are removed until breathiness occurs. The two sides are staged; that is, one side is done at a time, with surgery on the second side being performed 3 to 6 months after that on the first side, if needed.
This was a retrospective, unblinded study of 5 patients who underwent myectomy of the thyroarytenoid and lateral cricoarytenoid muscles. The preliminary results show improved voice fluency in all patients at 5 to 19 months of follow-up. There was no period of prolonged breathiness or dysphagia in any of the patients, and there were no surgical complications.
Myectomy of the thyroarytenoid and lateral cricoarytenoid muscles is a promising new surgical treatment for adductor-type spasmodic dysphonia that may effectively mimic "permanent" botulinum toxin injections.
尽管人们认为无震颤的内收型痉挛性发声障碍代表一种中枢神经功能障碍过程,但通常通过注射A型肉毒杆菌毒素可有效治疗;然而,在大多数情况下,此类注射必须每隔几个月重复进行。本文报道了一种有前景的新手术方法。
在局部麻醉并静脉镇静的情况下,创建一个大的喉成形术窗口,并在术中语音监测的直视下,切除甲杓肌和环杓侧肌的纤维,直至出现呼吸音。分两侧进行手术;也就是说,一次只做一侧,如果需要,在第一侧手术后3至6个月再进行第二侧手术。
这是一项对5例行甲杓肌和环杓侧肌切除术患者的回顾性、非盲法研究。初步结果显示,在5至19个月的随访中,所有患者的语音流畅性均有所改善。所有患者均未出现长时间的呼吸音或吞咽困难,也没有手术并发症。
甲杓肌和环杓侧肌切除术是一种有前景的新手术治疗方法,可有效模拟“永久性”A型肉毒杆菌毒素注射,用于治疗内收型痉挛性发声障碍。