安慰剂反应的心理生物学

Psychobiology of the placebo response.

作者信息

Klosterhalfen Sibylle, Enck Paul

机构信息

Institute for Medical Psychology, University Hospitals Duesseldorf, Germany.

出版信息

Auton Neurosci. 2006 Apr 30;125(1-2):94-9. doi: 10.1016/j.autneu.2006.01.015. Epub 2006 Mar 3.

DOI:10.1016/j.autneu.2006.01.015

PMID:16515893

Abstract

The nature and determinants of the placebo response are widely unknown and are discussed controversially. This review presents a unifying concept for the understanding of the placebo response in clinical trials and practice based on three components: "Regression to the mean", "Pavlovian conditioning", and "Signal detection theory", and discusses the respective literature in light of experimental and clinical findings from psychology, psychiatry, neurology, and gastroenterology, with specific emphasis on "brain imaging" of the placebo response.

摘要

安慰剂反应的本质和决定因素尚不为人所知，且存在诸多争议。本综述基于“均值回归”“巴甫洛夫条件反射”和“信号检测理论”这三个要素，提出了一个用于理解临床试验和实践中安慰剂反应的统一概念，并结合心理学、精神病学、神经病学和胃肠病学的实验及临床研究结果，对相关文献进行了讨论，特别强调了安慰剂反应的“脑成像”研究。