非糖尿病性良性前列腺增生症中的高胰岛素血症和血脂异常

Hyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia.

作者信息

Nandeesha H, Koner B C, Dorairajan L N, Sen S K

机构信息

Department of Biochemistry, Jawaharlal Nehru Institute of Postgraduate Medical Education and Research, Pondicherry-605006, India.

出版信息

Clin Chim Acta. 2006 Aug;370(1-2):89-93. doi: 10.1016/j.cca.2006.01.019. Epub 2006 Mar 3.

DOI:10.1016/j.cca.2006.01.019

PMID:16516184

Abstract

BACKGROUND

BPH is a multifactorial disease. Several studies have elucidated the role of hormones and growth factors in its etiology. Insulin is a growth-stimulating hormone. Previous studies have reported the association between hyperinsulinemia, dyslipidemia and BPH in patients with metabolic disorders like diabetes. We evaluated insulin and lipid profile parameters in non-diabetic BPH cases and correlated it with prostate size.

METHODS

50 symptomatic BPH cases and 38 controls were included in this study. Fasting serum insulin concentrations were measured by radioimmunoassay. Insulin resistance was assessed by HOMA. Fasting glucose, total cholesterol and triglycerides were quantified by enzymatic methods. HDL-cholesterol was quantified by phosphotungstate magnesium chloride method. LDL-cholesterol was calculated by Friedwald's formula.

RESULTS

Fasting serum insulin, HOMA, total cholesterol, and LDL-cholesterol were significantly higher and HDL-cholesterol was significantly lower in cases as compared to controls. Insulin was significantly associated with prostate size, cholesterol, triglycerides, VLDL-cholesterol and LDL-cholesterol in BPH cases. Stepwise regression analysis showed insulin as an independent risk factor in the development of BPH.

CONCLUSIONS

Hyperinsulinemia associated with insulin resistance is an independent risk factor in the development of BPH.

摘要

背景

良性前列腺增生（BPH）是一种多因素疾病。多项研究阐明了激素和生长因子在其病因学中的作用。胰岛素是一种生长刺激激素。既往研究报道了在糖尿病等代谢紊乱患者中高胰岛素血症、血脂异常与BPH之间的关联。我们评估了非糖尿病BPH患者的胰岛素和血脂参数，并将其与前列腺大小进行关联分析。

方法

本研究纳入了50例有症状的BPH患者和38例对照。采用放射免疫分析法测定空腹血清胰岛素浓度。通过稳态模型评估法（HOMA）评估胰岛素抵抗。采用酶法测定空腹血糖、总胆固醇和甘油三酯。采用磷钨酸氯化镁法测定高密度脂蛋白胆固醇（HDL-胆固醇）。采用弗里德瓦尔德公式计算低密度脂蛋白胆固醇（LDL-胆固醇）。