Hillemacher Thomas, Bayerlein Kristina, Frieling Helge, Wilhelm Julia, Ziegenbein Marc, Kornhuber Johannes, Bleich Stefan
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany.
J Psychiatr Res. 2007 Oct;41(8):702-6. doi: 10.1016/j.jpsychires.2006.01.009. Epub 2006 Mar 3.
Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures.
We assessed 118 male patients admitted for detoxification treatment. Previous withdrawal seizures were recorded and prolactin serum levels were measured using an enzymatic immunoassay.
Patients with a history of alcohol withdrawal seizures had significantly higher prolactin levels (17.8 ng/ml, SD=12.1) than patients without previous seizures (13.0 ng/ml, SD=8.1, p<0.05). Logistic regression revealed significant predictive qualities for prolactin serum levels (B=0.05, Wald=5.30, p=0.021, OR=1.06, 95%CI=1.01-1.11).
The present findings show an association between elevated prolactin serum levels and a history of withdrawal seizures. Hence, the results suggest that prolactin elevation at admission may be a clinical marker for an increased risk of withdrawal seizures.
催乳素已被讨论可用于癫痫的鉴别诊断。本研究的目的是调查血清催乳素水平与既往酒精戒断性癫痫发作之间的关联。
我们评估了118名因戒毒治疗入院的男性患者。记录既往戒断性癫痫发作情况，并使用酶免疫测定法测量血清催乳素水平。
有酒精戒断性癫痫发作史的患者催乳素水平（17.8 ng/ml，标准差=12.1）显著高于无既往癫痫发作史的患者（13.0 ng/ml，标准差=8.1，p<0.05）。逻辑回归显示血清催乳素水平具有显著的预测价值（B=0.05，Wald=5.30，p=0.021，OR=1.06，95%置信区间=1.01-1.11）。
目前的研究结果表明血清催乳素水平升高与戒断性癫痫发作史之间存在关联。因此，结果提示入院时催乳素升高可能是戒断性癫痫发作风险增加的临床标志物。
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