谷胱甘肽S-转移酶M1基因多态性与口腔白斑

GSTM1 polymorphism and oral leukoplakia.

作者信息

Duarte Eliza Carla Barroso, da Silva Marina Sena Lopes, Gomez Marcus Vinícius, Gomez Ricardo Santiago

机构信息

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de of Minas Gerais, Belo Horizonte, Brazil.

出版信息

J Oral Pathol Med. 2006 Apr;35(4):202-5. doi: 10.1111/j.1600-0714.2006.00405.x.

DOI:10.1111/j.1600-0714.2006.00405.x

PMID:16519766

Abstract

BACKGROUND

Molecular epidemiological studies have now provided evidence that an individual susceptibility to cancer is mediated by genetic and environmental factors. Genetic polymorphisms have been described for enzymes involved in the metabolism of tobacco carcinogens and cancer risk is determined by the degree of expression and/or activity of enzymes involved in carcinogen activation or deactivation. The objective of this study was to investigate the GSTM1 null polymorphism and the risk for oral leukoplakia in individuals with tobacco-smoking habit in a Brazilian population.

METHODS

A total of 52 tobacco-smoking patients with oral leukoplakia and 52 tobacco-smoking controls were recruited in a Brazilian population. The GSTM1 genotypes were studied by polymerase chain reaction-based methods.

RESULTS

The frequency of the GSTM1 null genotype in the group with oral leukoplakia (57.7%) was statistically different from the controls (34.6%; OR: 2.57, 95% CI: 1.16-5.69, P < 0.05). The stratification of the samples according to the level of dysplasia showed increased prevalence of GSTM1 null genotype on lesions with moderate/severe histological dysplasia (68.2%) compared with the control group (31.9%). This difference was statistically significant (OR: 4.59, 95% CI: 1.29-16.33, P < 0.05).

CONCLUSION

In conclusion, the GSTM1 null genotype may increase the risk for oral leukoplakia development.

摘要

背景

分子流行病学研究现已提供证据表明，个体对癌症的易感性由遗传和环境因素介导。已描述了参与烟草致癌物代谢的酶的基因多态性，癌症风险由参与致癌物激活或失活的酶的表达程度和/或活性决定。本研究的目的是调查巴西人群中有吸烟习惯的个体中谷胱甘肽硫转移酶M1（GSTM1）基因缺失多态性与口腔白斑病风险的关系。

方法

在巴西人群中招募了52例有口腔白斑病的吸烟患者和52例吸烟对照者。通过基于聚合酶链反应的方法研究GSTM1基因分型。

结果

口腔白斑病组中GSTM1基因缺失基因型的频率（57.7%）与对照组（34.6%）在统计学上有差异（比值比：2.57，95%置信区间：1.16 - 5.69，P < 0.05）。根据发育异常程度对样本进行分层显示，与对照组（31.9%）相比，中度/重度组织学发育异常病变中GSTM1基因缺失基因型的患病率增加（68.2%）。这种差异具有统计学意义（比值比：4.59，95%置信区间：1.29 - 16.33，P < 0.05）。