Timofeev Ivan, Gupta Arun
Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK.
Curr Opin Anaesthesiol. 2005 Oct;18(5):477-83. doi: 10.1097/01.aco.0000183107.19673.ed.
This article reviews recent advances in multimodality monitoring of patients following severe head injury during the period of 2004-2005.
Whilst intracranial pressure measurement remains the cornerstone of neuromonitoring, analysis of the intracranial pressure waveform provides additional information, which may help guide treatment and predict outcome. Non-invasive detection of intracranial hypertension and assessment of cerebral perfusion pressure and autoregulation is the focus of ongoing research. Although jugular venous saturation monitoring remains a useful method for detecting global hypoperfusion its sensitivity to regional ischaemia is low. Brain tissue oxygen monitoring overcomes this deficiency and sheds new light on the pathophysiology of cerebral ischaemia following brain injury. Further studies are required to define ischaemic thresholds and their association with outcome. Extracellular brain pH has been recently linked to outcome and further studies are required to establish the role of pH regulation. Monitoring of brain metabolism using a cerebral microdialysis continues to develop its niche in clinical neuromonitoring, although it currently remains a research tool.
Multimodality neuromonitoring plays an important role in managing patients with severe head injury. It helps guide treatment, provides prognostic information and explores the pathophysiology of evolving brain injury.
本文回顾了2004 - 2005年期间重型颅脑损伤患者多模态监测的最新进展。
虽然颅内压测量仍然是神经监测的基石,但对颅内压波形的分析可提供额外信息,这可能有助于指导治疗和预测预后。颅内高压的无创检测以及脑灌注压和自动调节功能的评估是当前研究的重点。尽管颈静脉血氧饱和度监测仍然是检测全身性低灌注的有用方法,但其对局部缺血的敏感性较低。脑组织氧监测克服了这一缺陷,并为脑损伤后脑缺血的病理生理学提供了新的见解。需要进一步研究来确定缺血阈值及其与预后的关系。细胞外脑pH值最近已与预后相关联,需要进一步研究来确定pH调节的作用。使用脑微透析监测脑代谢在临床神经监测中继续发挥其独特作用,尽管它目前仍然是一种研究工具。
多模态神经监测在重型颅脑损伤患者的管理中发挥着重要作用。它有助于指导治疗,提供预后信息,并探索不断演变的脑损伤的病理生理学。