功能性中央多聚嘌呤序列为1型人类免疫缺陷病毒基因组提供下游保护，使其免受载脂蛋白B mRNA编辑酶催化多肽样蛋白3G（APOBEC3G）和载脂蛋白B mRNA编辑酶催化多肽样蛋白3B（APOBEC3B）的编辑。
Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B.
作者信息
Wurtzer Sebastien, Goubard Armelle, Mammano Fabrizio, Saragosti Sentob, Lecossier Denise, Hance Allan J, Clavel François
机构信息
Unité de Recherche Antivirale, INSERM U552, Paris, France.
出版信息
J Virol. 2006 Apr;80(7):3679-83. doi: 10.1128/JVI.80.7.3679-3683.2006.
Abstract
Lentiviruses utilize two polypurine tracts for initiation of plus-strand viral DNA synthesis. We have examined to what extent human immunodeficiency virus type 1 plus-strand initiation at the central polypurine tract (cPPT) could protect the viral genome from DNA editing by APOBEC3G and APOBEC3B. The presence of a functional cPPT, but not of a mutated cPPT, extensively reduced editing by both APOBEC3G and APOBEC3B of sequences downstream, but not upstream, of the cPPT, with significant protection observed as far as 400 bp downstream. Thus, in addition to other potential functions, the cPPT could help protect lentiviruses from editing by cytidine deaminases of the APOBEC family.
摘要
慢病毒利用两个多聚嘌呤序列来起始正链病毒DNA的合成。我们已经研究了人类免疫缺陷病毒1型在中央多聚嘌呤序列（cPPT）处的正链起始在多大程度上能够保护病毒基因组免受载脂蛋白B mRNA编辑酶催化多肽样3G（APOBEC3G）和载脂蛋白B mRNA编辑酶催化多肽样3B（APOBEC3B）的DNA编辑。功能性cPPT的存在，而非突变型cPPT的存在，能显著减少cPPT下游（而非上游）序列被APOBEC3G和APOBEC3B编辑的程度，在下游400 bp处仍观察到显著的保护作用。因此，除了其他潜在功能外，cPPT可能有助于保护慢病毒免受APOBEC家族胞嘧啶脱氨酶的编辑。
相似文献
1
Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B.
J Virol. 2006 Apr;80(7):3679-83. doi: 10.1128/JVI.80.7.3679-3683.2006.
2
The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.
Virology. 2007 Aug 1;364(2):486-93. doi: 10.1016/j.virol.2007.03.019. Epub 2007 Apr 16.
3
Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8321-6. doi: 10.1073/pnas.0408223102. Epub 2005 May 26.
4
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
Nature. 2003 Jul 3;424(6944):99-103. doi: 10.1038/nature01709. Epub 2003 May 28.
5
Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons.
J Virol. 2007 Oct;81(19):10588-96. doi: 10.1128/JVI.02489-06. Epub 2007 Jul 25.
6
[The innate antiretroviral defense of human cells, based on the DNA editing].
Postepy Biochem. 2006;52(3):247-52.
7
The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.
J Virol. 2010 Nov;84(22):11981-93. doi: 10.1128/JVI.00723-10. Epub 2010 Sep 15.
8
APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism.
Med Sci Monit. 2006 May;12(5):RA92-8.
9
Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.
PLoS Biol. 2004 Sep;2(9):E275. doi: 10.1371/journal.pbio.0020275. Epub 2004 Jul 20.
10
Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation.
J Virol. 2007 Jul;81(13):7238-48. doi: 10.1128/JVI.02584-06. Epub 2007 Apr 11.
引用本文的文献
1
CAR-T cell potency: from structural elements to vector backbone components.
Biomark Res. 2022 Sep 19;10(1):70. doi: 10.1186/s40364-022-00417-w.
2
The Role of APOBECs in Viral Replication.
Microorganisms. 2020 Nov 30;8(12):1899. doi: 10.3390/microorganisms8121899.
3
retrotransposon virus-like particles and their regulation by epigenetically activated small RNA.
Genome Res. 2020 Apr;30(4):576-588. doi: 10.1101/gr.259044.119. Epub 2020 Apr 17.
4
Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance.
Heliyon. 2019 Apr 16;5(4):e01498. doi: 10.1016/j.heliyon.2019.e01498. eCollection 2019 Apr.
5
Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3G.
J Virol. 2017 Jan 18;91(3). doi: 10.1128/JVI.02230-16. Print 2017 Feb 1.
6
Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation.
PLoS Pathog. 2016 May 17;12(5):e1005646. doi: 10.1371/journal.ppat.1005646. eCollection 2016 May.
7
Reverse Transcription of Retroviruses and LTR Retrotransposons.
Microbiol Spectr. 2015 Apr;3(2):MDNA3-0027-2014. doi: 10.1128/microbiolspec.MDNA3-0027-2014.
8
Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes.
Viruses. 2013 Oct 7;5(10):2483-511. doi: 10.3390/v5102483.
9
Retroviral restriction factor APOBEC3G delays the initiation of DNA synthesis by HIV-1 reverse transcriptase.
PLoS One. 2013 May 23;8(5):e64196. doi: 10.1371/journal.pone.0064196. Print 2013.
10
The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis.
Virology. 2013 Jun 20;441(1):1-11. doi: 10.1016/j.virol.2013.03.010. Epub 2013 Apr 3.
本文引用的文献
1
Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors.
J Virol. 2005 Jul;79(14):8724-31. doi: 10.1128/JVI.79.14.8724-8731.2005.
2
Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.
Virology. 2005 Sep 1;339(2):281-8. doi: 10.1016/j.virol.2005.06.005.
3
The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein.
Proc Natl Acad Sci U S A. 2005 May 31;102(22):7982-7. doi: 10.1073/pnas.0501445102. Epub 2005 May 23.
4
Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues.
J Virol. 2005 Jan;79(2):812-22. doi: 10.1128/JVI.79.2.812-822.2005.
5
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
J Biol Chem. 2004 Dec 17;279(51):53379-86. doi: 10.1074/jbc.M408802200. Epub 2004 Oct 4.
6
Cytidine deamination of retroviral DNA by diverse APOBEC proteins.
Curr Biol. 2004 Aug 10;14(15):1392-6. doi: 10.1016/j.cub.2004.06.057.
7
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome.
Nat Struct Mol Biol. 2004 May;11(5):435-42. doi: 10.1038/nsmb758. Epub 2004 Apr 18.
8
Assessment of the role of the central DNA flap in human immunodeficiency virus type 1 replication by using a single-cycle replication system.
J Virol. 2004 Mar;78(6):3170-7. doi: 10.1128/jvi.78.6.3170-3177.2004.
9
DNA deamination mediates innate immunity to retroviral infection.
Cell. 2003 Jun 13;113(6):803-9. doi: 10.1016/s0092-8674(03)00423-9.
10
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
Nature. 2003 Jul 3;424(6944):99-103. doi: 10.1038/nature01709. Epub 2003 May 28.
Zotero 插件