Muro Enrique M, Perez-Iratxeta Carolina, Andrade-Navarro Miguel A
Ontario Genomics Innovation Centre, Ottawa Health Research Institute, 501 Smyth Rd, Ottawa ON, K1H 8L6, Canada .
BMC Bioinformatics. 2006 Mar 20;7:159. doi: 10.1186/1471-2105-7-159.
The annotations of Affymetrix DNA microarray probe sets with Gene Ontology terms are carefully selected for correctness. This results in very accurate but incomplete annotations which is not always desirable for microarray experiment evaluation.
Here we present a protocol to amplify the set of Gene Ontology annotations associated to Affymetrix DNA microarray probe sets using information from related databases.
Predicted novel annotations and the evidence producing them can be accessed at Probe2GO: http://www.ogic.ca/p2g. Scripts are available on demand.
Affymetrix DNA微阵列探针集与基因本体论术语的注释经过精心挑选以确保正确性。这导致注释非常准确但不完整,而这对于微阵列实验评估而言并非总是理想的。
在此,我们提出一种方案,利用来自相关数据库的信息来扩充与Affymetrix DNA微阵列探针集相关的基因本体论注释集。