小鼠持续性淋巴细胞脉络丛脑膜炎病毒感染：病毒特异性免疫耐受。
Persistent infection of mice with the virus of lymphocytic choriomeningitis: virus-specific immunological tolerance.
机构信息
Heinrich-Pette-Institut für experimentelle Virologie und Immunologie an der Universität Hamburg, Hamburg, Federal Republic of Germany.
出版信息
Infect Immun. 1974 Nov;10(5):1072-6. doi: 10.1128/iai.10.5.1072-1076.1974.
Lymphocytic choriomeningitis (LCM) virus-infected culture cells as targets were markedly reduced in numbers when incubated in vitro with spleen cells from LCM virus-immune mice, even if the cells were taken months after a subcutaneous immunizing infection of the donor animal. Spleen cells from mice persistently infected with LCM virus had no effect on target cells. Also, mitomycin C-blocked LCM virus-infected culture cells stimulated the incorporation of radiolabeled thymidine into spleen cells from LCM virus-immune mice. No stimulation was observed with spleen cells from LCM virus carrier mice. It was concluded that cell-mediated immunity directed against LCM virion surface antigen(s) is absent in LCM virus carrier mice.
淋巴细胞性脉络丛脑膜炎病毒（LCM）感染的培养细胞在体外与来自 LCM 病毒免疫小鼠的脾细胞孵育时，数量明显减少，即使这些细胞是在供体动物皮下免疫感染数月后取出的。持续感染 LCM 病毒的小鼠的脾细胞对靶细胞没有影响。此外，丝裂霉素 C 阻断的 LCM 病毒感染的培养细胞刺激 LCM 病毒免疫小鼠的脾细胞掺入放射性标记的胸腺嘧啶。用 LCM 病毒携带者的脾细胞观察不到刺激。因此得出结论，LCM 病毒携带者的小鼠中不存在针对 LCM 病毒粒子表面抗原的细胞介导免疫。
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