(+)-N-去氧米里塔诺酮A，一种来自昆虫病原真菌粉拟青霉的促神经突生长吡啶酮生物碱。

(+)-N-Deoxymilitarinone A, a neuritogenic pyridone alkaloid from the insect pathogenic fungus Paecilomyces farinosus.

作者信息

Cheng Yongxian, Schneider Bernd, Riese Ulrike, Schubert Barbara, Li Zengzhi, Hamburger Matthias

机构信息

Institute of Pharmacy, Friedrich-Schiller-University Jena, Germany.

出版信息

J Nat Prod. 2006 Mar;69(3):436-8. doi: 10.1021/np050418g.

DOI:10.1021/np050418g

PMID:16562854

Abstract

A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3beta,5alpha,6beta,9alpha-tetraol was also identified. The structures were established by spectroscopic methods, in particular with the aid of extensive NMR experiments. Compound 1 induced neurite sprouting in PC 12 cells when tested at 33 and 100 microM concentrations. A cytotoxic effect was observed in human neurons (IMR-32) at a concentration of 100 microM.

摘要

从粉拟青霉RCEF 0097中分离出一种新的吡啶酮生物碱，(+)-N-去氧米卡霉素A（1），以及相关代谢产物米卡霉素D和米卡霉素B。还鉴定出了甾醇22E,4R-麦角甾-7,22-二烯-3β,5α,6β,9α-四醇。通过光谱方法，特别是借助广泛的核磁共振实验确定了其结构。化合物1在33和100微摩尔浓度下进行测试时，可诱导PC 12细胞中的神经突萌发。在100微摩尔浓度下，在人神经元（IMR-32）中观察到细胞毒性作用。