[心房易激期对山羊心房颤动稳定性的影响]
[Effects of atrial excitable period on the stability of atrial fibrillation in goats].
作者信息
Shan Zhao-liang, Wang Yu-tang, Shi Xiang-min, Yan Jun-jin, Zhou Jun-yan, Guo Jian-ping, Wang Wei-hua, Li Tian-de
机构信息
Department of Cardiology, General Hospital of PLA, Beijing 100853, China.
出版信息
Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Nov;33(11):992-4.
OBJECTIVE
To investigate the effects of atrial excitable period (EP) on the stability of atrial fibrillation (AF) in goats.
METHODS
Ten female goats were instrumented with epicardial electrodes patches on the left atrium (LA) free wall. AF was induced and maintained by a home-made stimulator with frequency of 50 Hz at a 1-second duration and a 2-seconds interval. The stimulator was disconnected regularly. AF-induced duration, average AF cycle length (AFCL), and atrial effective refractory period during AF (ERP(AF)) were measured; EP was calculated by AFCL-ERP(AF).
RESULTS
Eight goats were studied. Persistent AF (> 24 h) could be induced in all the 8 goats within 6-16 days. When the induced AF lasted for 3-10 min or 24 h, the AFCL was 98.3 ms +/- 11.0 ms and 84.9 ms +/- 5.2 ms (P < 0.05), respectively, ERP(AF) was 90.5 ms +/- 13.2 ms and 63.0 ms +/- 4.8 ms (P < 0.05), respectively, and EP was 7.8 ms +/- 2.4 ms and 21.9 ms +/- 3.5 ms (P < 0.05), respectively.
CONCLUSION
The decrease in ERP(AF) is more significant than the shortening in AFCL, resulting in the gradually widening of EP which may contribute to the perpetuation of AF.
目的
研究山羊心房可兴奋期（EP）对心房颤动（AF）稳定性的影响。
方法
对10只雌性山羊在左心房（LA）游离壁植入心外膜电极片。使用自制刺激器以50Hz频率、1秒持续时间和2秒间隔诱发并维持AF。刺激器定期断开。测量诱发AF的持续时间、平均AF周期长度（AFCL）以及AF期间的心房有效不应期（ERP(AF)）；EP通过AFCL - ERP(AF)计算得出。
结果
对8只山羊进行了研究。所有8只山羊均在6 - 16天内诱发出持续性AF（> 24小时）。当诱发的AF持续3 - 10分钟或24小时时，AFCL分别为98.3 ms ± 11.0 ms和84.9 ms ± 5.2 ms（P < 0.05），ERP(AF)分别为90.5 ms ± 13.2 ms和63.0 ms ± 4.8 ms（P < 0.05），EP分别为7.8 ms ± 2.4 ms和21.9 ms ± 3.5 ms（P < 0.05）。
结论
AF期间ERP(AF)的降低比AFCL的缩短更显著，导致EP逐渐增宽，这可能促使AF持续存在。
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