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澳大利亚儿童免疫接种的及时性。

Timeliness of childhood immunisation in Australia.

作者信息

Hull Brynley P, McIntyre Peter B

机构信息

National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Children's Hospital at Westmead and the University of Sydney, NSW, Australia.

出版信息

Vaccine. 2006 May 15;24(20):4403-8. doi: 10.1016/j.vaccine.2006.02.049. Epub 2006 Mar 13.

Abstract

There are few data, especially outside the United States, examining the timeliness of childhood vaccination, although it is of key importance for diseases such as pertussis, and invasive disease due to Haemophilus influenzae type b and Streptococcus pneumoniae. The aim of this study was to use the unique resource of the Australian Childhood Immunisation Register (ACIR) to examine trends in and factors associated with timeliness of infant vaccination at the national level. As in previous studies, age-appropriate immunisation was defined as within 30 days of the recommended age. Vaccination delays became more common for later doses, given at an older age, but long delay (greater than 6 months) occurred in only 1-2%. Although immunisation coverage increased over time, timeliness did not improve. Among Indigenous infants, long delays occurred in 5-12% of those residing in very remote areas, but by 2 years of age, overall immunisation coverage was similar to non-Indigenous children. With immunisation coverage at the key indicator ages of 12 and 24 months now high in most industrialised countries including Australia, timeliness of vaccine doses should be the next benchmark to aim for in program performance, especially in specific sub-groups such as Indigenous children who stand to gain most from prevention of early onset disease.

摘要

关于儿童疫苗接种及时性的数据很少,尤其是在美国以外的地区,尽管对于百日咳、b型流感嗜血杆菌和肺炎链球菌引起的侵袭性疾病等疾病而言,疫苗接种及时性至关重要。本研究的目的是利用澳大利亚儿童免疫接种登记册(ACIR)这一独特资源,在国家层面研究婴儿疫苗接种及时性的趋势及其相关因素。与以往研究一样,适龄免疫接种被定义为在推荐年龄的30天内。随着接种年龄增大,后续剂次的疫苗接种延迟更为常见,但长延迟(超过6个月)仅发生在1%-2%的情况中。尽管免疫接种覆盖率随时间有所提高,但及时性并未改善。在原住民婴儿中,居住在极偏远地区的婴儿中有5%-12%出现长延迟,但到2岁时,总体免疫接种覆盖率与非原住民儿童相似。在包括澳大利亚在内的大多数工业化国家,12个月和24个月这两个关键指标年龄的免疫接种覆盖率目前都很高,疫苗接种剂次的及时性应成为计划执行中的下一个目标基准,特别是在原住民儿童等特定亚组中,他们从预防早期发病中获益最大。

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