[从土贝母块茎中分离并鉴定一种生物活性皂苷]
[Isolation and structural elucidation of a bioactive saponin from tubers of Bolbostemma paniculatum].
作者信息
Tang Hai-Feng, Zhang Shu-Yu, Yi Yang-Hua, Wen Ai-Dong, Zhao Yue-Ping, Wang Zhong-Zhuang
机构信息
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Feb;31(3):213-7.
OBJECTIVE
To study the bioactive constituents from tubers of Bolbostemma paniculatum.
METHOD
Compounds were isolated by extraction and partition as well as several-chromatographic techniques guided with Pyricularia oryzae bioassay method. Their structures were determined on the basis of spectral analysis and chemical evidence.
RESULT
Bisdesmoside (I) was isolated as active compound causing morphological abnormality of Pyncularia oryzae mycelia and elucidated as 3-0-alpha-L-arabinopyranosyl (1-->2)-beta-D-glucopyranosyl-bayogenin-28-O-beta-D-xylopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside.
CONCLUSION
I is a new natural product and exhibited significant cytotoxicity against cancer cell lines K-562 and BEL-7402, but no hemolytic activity to rabbit erythrocytes.
目的
研究土贝母块茎中的生物活性成分。
方法
采用提取、分离及多种色谱技术，并以稻瘟霉生物活性测定法为导向进行化合物分离。通过光谱分析和化学证据确定其结构。
结果
双糖苷（I）被分离为导致稻瘟霉菌丝体形态异常的活性化合物，经鉴定为3-O-α-L-阿拉伯吡喃糖基（1→2）-β-D-吡喃葡萄糖基-贝母皂苷元-28-O-β-D-木吡喃糖基（1→3）-α-L-鼠李吡喃糖基（1→2）-α-L-阿拉伯吡喃糖苷。
结论
I是一种新的天然产物，对癌细胞系K-562和BEL-7402具有显著的细胞毒性，但对兔红细胞无溶血活性。
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