心尖球囊样变（应激性心肌病）综合征中局部心肌葡萄糖摄取的急性受损
Acute impairment of regional myocardial glucose uptake in the apical ballooning (takotsubo) syndrome.
作者信息
Bybee Kevin A, Murphy Joseph, Prasad Abhiram, Wright R Scott, Lerman Amir, Rihal Charanjit S, Chareonthaitawee Panithaya
机构信息
Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.
出版信息
J Nucl Cardiol. 2006 Mar-Apr;13(2):244-50. doi: 10.1007/BF02971249.
BACKGROUND
Apical ballooning syndrome (ABS) is a poorly understood clinical entity characterized by acute, transient systolic dysfunction of the left ventricular (LV) apex in the absence of epicardial coronary artery disease and commonly associated with acute emotional stress. We report abnormal regional myocardial perfusion and glucose uptake in 4 consecutive ABS patients studied using positron emission tomography with 13N-ammonia and 18F-fluorodeoxyglucose within 72 hours of presentation with ABS.
METHODS
All patients were postmenopausal females, 3 of whom had a major recent life stress event. Coronary angiography revealed no or minimal obstructive epicardial coronary artery disease. All patients exhibited reduced glucose uptake in the mid-LV and apical myocardial segments, which was out of proportion to perfusion abnormalities in half of the cases.
CONCLUSION
In all 4 patients, affected regions subsequently recovered regional LV systolic function within 6 weeks.
背景
心尖气球样变综合征（ABS）是一种了解较少的临床病症，其特征为在无冠状动脉疾病的情况下，左心室（LV）心尖出现急性、短暂的收缩功能障碍，且通常与急性情绪应激相关。我们报告了4例连续的心尖气球样变综合征患者，在出现该病症72小时内使用13N-氨和18F-氟脱氧葡萄糖进行正电子发射断层扫描研究，发现其局部心肌灌注和葡萄糖摄取异常。
方法
所有患者均为绝经后女性，其中3人近期有重大生活应激事件。冠状动脉造影显示无或仅有轻微的冠状动脉阻塞性疾病。所有患者均表现出左心室中部和心尖心肌节段葡萄糖摄取减少，其中半数病例中葡萄糖摄取减少与灌注异常不成比例。
结论
所有4例患者受影响区域随后在6周内恢复了左心室局部收缩功能。
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