来源于细梗香草的三种新型三萜皂苷及其细胞毒性活性。

Three novel triterpenoid saponins from Lysimachia capillipes and their cytotoxic activities.

作者信息

Tian Jing-Kui, Xu Li-Zhen, Zou Zhong-Mei, Yang Shi-Lin

机构信息

Department of Chinese Medicine Sciences & Engineering, Zhejiang University, Hangzhou, China.

出版信息

Chem Pharm Bull (Tokyo). 2006 Apr;54(4):567-9. doi: 10.1248/cpb.54.567.

DOI:10.1248/cpb.54.567

PMID:16595968

Abstract

Three new saponins, capilliposide A (1), capilliposide B (2) and capilliposide C (3) were isolated from an ethanol extract of Lysimachia capillipes. Their structures were determined by 1D and 2D NMR (1H-1H COSY, HMBC, HMQC, DEPT and TOCSY) techniques, MS, and hydrolysis. Capilliposide B showed significant cytotoxicity against human A-2780 cells.

摘要

从细梗香草乙醇提取物中分离得到3个新皂苷，分别为细梗香草苷A（1）、细梗香草苷B（2）和细梗香草苷C（3）。通过一维和二维核磁共振（1H-1H COSY、HMBC、HMQC、DEPT和TOCSY）技术、质谱及水解反应确定了它们的结构。细梗香草苷B对人A-2780细胞显示出显著的细胞毒性。