Raska Milan, Weigl Evzen
Department of Immunology, Palacky University in Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):243-9. doi: 10.5507/bp.2005.033.
Heat shock proteins (hsp's) are among the most conserved proteins in evolution. They have been identified as important pathogen-related antigens as well as autoantigens suitable for construction of novel vaccines. The high evolutionary homology of hsp's has raised the question about the safety of such vaccines. Experimental and clinical observations have confirmed that hsp proteins are involved in the regulation of some autoimmune disease such as autoimmune arthritis, type 1 diabetes mellitus, atherosclerosis, multiple sclerosis, and other autoimmune reactions. It has been shown in experimental animals that some hsp proteins (especially hsp60, hsp70, and hsp10) can either induce or prevent autoimmune reactions depending on the circumstances. This article discusses the involvement of hsp proteins in the etiology of autoimmune diseases and it presents promising experimental data on the effects of immunization with hsp proteins in the prevention and therapy of autoimmune diseases.
热休克蛋白（hsp's）是进化过程中最保守的蛋白质之一。它们已被确定为重要的病原体相关抗原以及适合构建新型疫苗的自身抗原。hsp's的高度进化同源性引发了此类疫苗安全性的问题。实验和临床观察证实，hsp蛋白参与了某些自身免疫性疾病的调节，如自身免疫性关节炎、1型糖尿病、动脉粥样硬化、多发性硬化症以及其他自身免疫反应。在实验动物中已表明，某些hsp蛋白（尤其是hsp60、hsp70和hsp10）可根据具体情况诱导或预防自身免疫反应。本文讨论了hsp蛋白在自身免疫性疾病病因学中的作用，并展示了关于用hsp蛋白免疫在预防和治疗自身免疫性疾病方面效果的有前景的实验数据。
