Fenoglio Kristina A, Brunson Kristen L, Baram Tallie Z
Department of Anatomy/Neurobiology, University of California at Irvine, 92697-4475, USA.
Front Neuroendocrinol. 2006 Jul;27(2):180-92. doi: 10.1016/j.yfrne.2006.02.001. Epub 2006 Apr 17.
Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.
虽然遗传因素对大脑功能起着至关重要的作用,但包括压力在内的早期生活事件会对神经元功能产生持久影响。在这里,我们将海马体作为这些早期生活事件的目标,因为它在学习和记忆中起着关键作用。我们使用一种新型的未成熟啮齿动物模型,描述了慢性早期生活“心理”压力对海马体依赖的认知任务的有害影响。我们回顾了其中涉及的细胞机制,并讨论了应激介导分子,包括促肾上腺皮质激素释放激素,在应激影响海马神经元结构和功能过程中的作用。