Samson Yves, Bruandet Marie, Lejeune Marie, Deltour Sandrine, Grimaldi André
Urgences Cérébrovasculaires, Groupe Hospitalier Pitié-Salpêtrière et Université Pierre et Marie Curie-Paris VI, Paris.
Presse Med. 2006 Apr;35(4 Pt 2):696-8. doi: 10.1016/s0755-4982(06)74664-4.
Hyperglycemia is correlated with poor prognosis in ischemic strokes and also increases the risk of hemorrhagic transformation after thrombolysis. The toxicity of hyperglycemia, already well established in animals, is beginning to be clear for humans. On the other hand, the beneficial effect of insulin remains controversial in animals and has never been demonstrated in humans. Preliminary data, which suggest that the speed and quality of glycemic control may be decisive in the efficacy of treatment, merit testing in a randomized trial.
高血糖与缺血性卒中的不良预后相关,还会增加溶栓后出血转化的风险。高血糖的毒性在动物中已得到充分证实,对人类而言也开始变得清晰。另一方面,胰岛素的有益作用在动物中仍存在争议,且从未在人类中得到证实。初步数据表明血糖控制的速度和质量可能对治疗效果起决定性作用,值得在随机试验中进行检验。