一项关于不明原因不孕症中常规体外受精与卵胞浆内单精子注射的前瞻性随机试验。
A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility.
作者信息
Foong Shu C, Fleetham Judy A, O'Keane Joseph A, Scott Selma G, Tough Suzanne C, Greene Calvin A
机构信息
Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
出版信息
J Assist Reprod Genet. 2006 Mar;23(3):137-40. doi: 10.1007/s10815-005-9008-y. Epub 2006 Apr 19.
Abstract
PURPOSE
To compare outcomes in patients with unexplained infertility undergoing conventional in vitro fertilization (IVF) versus intracytoplasmic sperm injection (ICSI).
METHODS
Sixty women with unexplained infertility in a Canadian tertiary-level clinic were randomized to IVF or ICSI. Subjects underwent downregulation with gonadotropin-releasing hormone agonist prior to initiation of recombinant human follicle-stimulating hormone. The primary outcome measure was fertilization rate. Secondary outcomes included implantation rate, embryo quality, clinical pregnancy rate, and live birth rate.
RESULTS
There was no statistically significant difference in fertilization rate (77.2% IVF vs. 82.4% ICSI), implantation rate (38.2% IVF vs. 44.4% ICSI), clinical pregnancy rate (50% in each group), or live birth rate (46.7% IVF vs. 50% ICSI). There were two cases of failed fertilization in the IVF group. There was no significant difference in embryo quality between groups.
CONCLUSIONS
There were no differences in clinical outcomes associated with IVF versus ICSI in the treatment of unexplained infertility.
摘要
目的
比较接受常规体外受精（IVF）与卵胞浆内单精子注射（ICSI）的不明原因不孕症患者的治疗结果。
方法
加拿大一家三级诊所的60名不明原因不孕症女性被随机分为IVF组或ICSI组。在开始使用重组人促卵泡激素之前，受试者先用促性腺激素释放激素激动剂进行降调节。主要结局指标为受精率。次要结局包括着床率、胚胎质量、临床妊娠率和活产率。
结果
受精率（IVF组为77.2%，ICSI组为82.4%）、着床率（IVF组为38.2%，ICSI组为44.4%）、临床妊娠率（每组均为50%）或活产率（IVF组为46.7%，ICSI组为50%）在统计学上无显著差异。IVF组有2例受精失败。两组间胚胎质量无显著差异。
结论
在不明原因不孕症的治疗中，IVF与ICSI的临床结局无差异。
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Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study.卵胞浆内单精子注射提高了体外受精非男性因素适应证患者的受精率和优质胚胎形成率：一项前瞻性随机研究。
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Embryo development and chromosomal anomalies after ICSI: effect of the injection procedure.卵胞浆内单精子注射后的胚胎发育与染色体异常：注射操作的影响
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Should ICSI be the treatment of choice for all cases of in-vitro conception?对于所有体外受精的病例，卵胞浆内单精子注射都应作为首选治疗方法吗？
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Intracytoplasmic sperm injection versus in vitro fertilization for patients with a tubal factor as their sole cause of infertility: a prospective, randomized trial.输卵管因素为唯一不孕原因的患者行卵胞浆内单精子注射与体外受精的前瞻性随机试验。
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