Bemis Debra L, Capodice Jillian L, Costello Jennifer E, Vorys George C, Katz Aaron E, Buttyan Ralph
Department of Urology, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA.
Curr Urol Rep. 2006 May;7(3):166-74. doi: 10.1007/s11934-006-0017-x.
Having a high probability of experiencing prostate cancer during their lifetime, men are increasingly seeking protection against this disease with the use of over-the-counter dietary supplements containing herbs, vitamins, or plant-derived biochemical agents. The use of these agents for prostate cancer prevention is driven by epidemiology supporting the idea that regional diets and consumption of specific dietary components (certain herbs, vitamins, isoflavones, and polyphenols) are associated with a lower risk for prostate cancer, in conjunction with basic research that is defining molecules within food substances that kill or suppress growth of cultured human prostate cancer cells. Moreover, there is a sense that these dietary agents lack side effects, although this assumption often is faulty. Unfortunately, at this time, there is insufficient clinical evidence to support the widespread use of these dietary supplements for chemoprevention of prostate cancer, although ongoing clinical trials of the most promising vitamins and minerals are approaching conclusion.
由于男性一生中患前列腺癌的概率较高，他们越来越多地通过服用含有草药、维生素或植物衍生生化制剂的非处方膳食补充剂来预防这种疾病。流行病学研究支持这样的观点，即地区饮食和特定膳食成分（某些草药、维生素、异黄酮和多酚）的摄入与较低的前列腺癌风险相关，同时基础研究也在确定食物中的分子，这些分子能够杀死或抑制培养的人前列腺癌细胞的生长，这推动了这些制剂用于前列腺癌预防。此外，人们认为这些膳食制剂没有副作用，尽管这种假设往往是错误的。不幸的是，目前尚无足够的临床证据支持广泛使用这些膳食补充剂进行前列腺癌的化学预防，尽管最有前景的维生素和矿物质的临床试验即将得出结论。
