甲型血友病患者的心脏手术。

Cardiac surgery in a patient with haemophilia A.

作者信息

Eren A, Friedl R, Hannekum A, Gulbins H

机构信息

Department of Cardiac Surgery, University Hospital Ulm, Ulm, Germany.

出版信息

Thorac Cardiovasc Surg. 2006 Apr;54(3):212-4. doi: 10.1055/s-2005-872859.

DOI:10.1055/s-2005-872859

PMID:16639687

Abstract

In this report we describe the successful cardiac surgery in a patient with haemophilia A. To undergo to triple on-pump coronary artery bypass grafting the level of factor VIII was estimated to be 100 %, during the operation and the first postoperative week. To reach this level, bolus therapy with B-domain deleted recombinant factor VIII was administered in a low substitution scheme. There was no bleeding complication. The patient discharged on the 14th postoperative day.

摘要

在本报告中，我们描述了1例甲型血友病患者成功接受心脏手术的情况。为进行体外循环下冠状动脉旁路移植术三联手术，在手术期间及术后第一周，凝血因子VIII水平需维持在100%。为达到这一水平，采用低剂量替代方案给予B结构域缺失重组凝血因子VIII推注治疗。未发生出血并发症。患者于术后第14天出院。