Miyashita Naoyuki, Matsushima Toshiharu, Oka Mikio
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki.
Intern Med. 2006;45(7):419-28. doi: 10.2169/internalmedicine.45.1691. Epub 2006 May 1.
Community-acquired pneumonia (CAP) continues to be a major medical problem. Since CAP is a potentially fatal disease, early appropriate antibiotic treatment is vital. Epidemiologic studies have shown that in the combined cause-of-death category, pneumonia ranks fourth as the leading cause of death in Japan. Therefore, the Japanese Respiratory Society (JRS) provided guidelines for the management of CAP in adults in 2000. Because of evolving resistance to antimicrobials and advances in diagnosis, treatment and prevention of CAP, it is felt that an update should be provided every three years so that important developments can be highlighted and pressing questions can be answered. Thus, the guidelines committee updated its guidelines in 2005. The basic policy and main purposes of the JRS guidelines include; 1) prevention of bacterial resistance and 2) effective and long-term use of medical resources. The JRS guidelines have recommended the exclusion of potential and broad spectrum antibiotics, fluoroquinolones and carbapenems, from the list of first-choice drugs for empirical treatment. In addition, the JRS guidelines have recommended short-term usage of antibiotics of an appropriate dose and pathogen-specific treatment using rapid diagnostic methods if possible.
社区获得性肺炎(CAP)仍然是一个主要的医学问题。由于CAP是一种潜在的致命疾病,早期进行适当的抗生素治疗至关重要。流行病学研究表明,在综合死因类别中,肺炎在日本是第四大主要死因。因此,日本呼吸学会(JRS)于2000年发布了成人CAP管理指南。由于对抗微生物药物的耐药性不断演变以及CAP诊断、治疗和预防方面的进展,人们认为应每三年更新一次指南,以便突出重要进展并回答紧迫问题。因此,指南委员会于2005年对其指南进行了更新。JRS指南的基本政策和主要目的包括:1)预防细菌耐药性;2)有效且长期地利用医疗资源。JRS指南建议将潜在的广谱抗生素、氟喹诺酮类和碳青霉烯类排除在经验性治疗的首选药物清单之外。此外,JRS指南建议使用适当剂量的抗生素进行短期治疗,并尽可能采用快速诊断方法进行针对病原体的治疗。