MMWR Morb Mortal Wkly Rep. 2006 May 12;55(18):509-11.
Hepatitis B virus (HBV) infection is a major cause of cirrhosis and liver cancer in the United States. The Advisory Committee on Immunization Practices (ACIP) has recommended a comprehensive strategy to eliminate HBV transmission, including prevention of perinatal HBV transmission; universal vaccination of infants; catch-up vaccination of unvaccinated children and adolescents; and vaccination of unvaccinated adults at increased risk for infection. The incidence of acute hepatitis B has declined 75%, from 8.5 per 100,000 population in 1990 to 2.1 per 100,000 population in 2004, with the greatest declines (94%) among children and adolescents. Incidence remains highest among adults, who accounted for approximately 95% of the estimated 60,000 new infections in 2004. To measure hepatitis B vaccination coverage among adults, data were analyzed from the 2004 National Health Interview Survey (NHIS). This report summarizes the results of that analysis, which indicated that, during 2004, 34.6% of adults aged 18-49 years reported receiving hepatitis B vaccine, including 45.4% of adults at high risk for HBV infection. To accelerate elimination of HBV transmission in the United States, public health programs and clinical care providers should implement strategies to ensure that adults at high risk are offered hepatitis B vaccine.
乙型肝炎病毒(HBV)感染是美国肝硬化和肝癌的主要病因。免疫实践咨询委员会(ACIP)推荐了一项消除HBV传播的综合策略,包括预防围产期HBV传播;对婴儿进行普遍接种;对未接种疫苗的儿童和青少年进行补种;以及对感染风险增加的未接种疫苗的成年人进行接种。急性乙型肝炎的发病率已下降了75%,从1990年的每10万人8.5例降至2004年的每10万人2.1例,其中儿童和青少年的降幅最大(94%)。发病率在成年人中仍然最高,在2004年估计的6万例新感染病例中,成年人约占95%。为了衡量成年人的乙型肝炎疫苗接种覆盖率,对2004年全国健康访谈调查(NHIS)的数据进行了分析。本报告总结了该分析结果,结果表明,在2004年期间,18至49岁的成年人中有34.6%报告接种了乙型肝炎疫苗,其中HBV感染高危成年人的接种率为45.4%。为了加速在美国消除HBV传播,公共卫生项目和临床护理提供者应实施策略,确保为高危成年人提供乙型肝炎疫苗。