泰国孔敬府诗里拉吉医院护理人员的手套过敏及对天然橡胶乳胶的致敏情况

Glove allergy and sensitization to natural rubber latex among nursing staff at Srinagarind Hospital, Khon Kaen, Thailand.

作者信息

Chaiear N, Jindawong B, Boonsawas W, Kanchanarach T, Sakunkoo P

机构信息

Unit of Occupational Medicine, Department of Community Medicine, Faculty of Medicine, Khon Kaen University, Thailand.

出版信息

J Med Assoc Thai. 2006 Mar;89(3):368-76.

PMID:16696422

Abstract

BACKGROUND

According to studies from different countries, the prevalence of natural rubber latex (NRL) sensitization in healthcare workers ranges from 2.9 to 17%. The incidence and prevalence of sensitization and allergy to NRL in Thailand is limited to two studies. There is no study among the high risk healthcare workers.

OBJECTIVES

To estimate the prevalence of natural rubber latex (NRL) glove allergy and NRL sensitization among nurses; 2) To describe its clinical symptoms.

MATERIAL AND METHOD

Included in the present study were 412 nursing and medical record staff. A self-administered questionnaire was used to collect personal biodata and individual allergy histories to NRL products. Skin prick tests (SPTs) with the commercial NRL allergens; Stallergènes, S.A, Fresnes, France, and common environmental allergens, were performed.

RESULTS

The questionnaire response rate was 88% (412/470), 93% females. The response rate of SPT was 72% (295/412) (95%CI 67.2, 76.0). The prevalence of NRL glove allergic symptoms and NRL sensitization was 24% (95%CI 19.9, 28.1) and 2% (95%CI 0.4, 3.6), respectively. The mostfrequently reported symptoms among the positive SPT to NRL was angioedema. Five of the six NRL sensitised subjects had had high exposure to NRL.

CONCLUSION

NRL sensitization among Thai nursing staff is less prevalent than in healthcare workers in Europe.

摘要

背景

根据不同国家的研究，医护人员中天然橡胶乳胶（NRL）致敏的患病率在2.9%至17%之间。泰国关于NRL致敏和过敏的发病率及患病率的研究仅有两项。针对高风险医护人员尚未开展相关研究。

目的

1）评估护士中天然橡胶乳胶（NRL）手套过敏和NRL致敏的患病率；2）描述其临床症状。

材料与方法

本研究纳入了412名护理及病历工作人员。采用自行填写的问卷收集个人生物数据以及对NRL产品的个人过敏史。使用法国弗雷斯内斯的Stallergènes, S.A公司生产的商用NRL过敏原及常见环境过敏原进行皮肤点刺试验（SPT）。

结果

问卷回复率为88%（412/470），女性占93%。SPT的回复率为72%（295/412）（95%置信区间67.2, 76.0）。NRL手套过敏症状和NRL致敏的患病率分别为24%（95%置信区间19.9, 28.1）和2%（95%置信区间0.4, 3.6）。NRL皮肤点刺试验阳性者中最常报告的症状是血管性水肿。6名NRL致敏受试者中有5名曾高度接触NRL。