Dolk Helen, Parkes Jackie, Hill Nan
Faculty of Life and Health Sciences, University of Ulster at Jordanstown, Newtownabbey, County Antrim, UK.
Dev Med Child Neurol. 2006 Jun;48(6):406-12; discussion 405. doi: 10.1017/S0012162206000909.
We describe trends in the prevalence of cerebral palsy (CP) by birthweight group, and in the severity of motor impairments and presence of associated intellectual impairment, in Northern Ireland from 1981 to 1997 (n=909; 510 males, 399 females; total population 415,936 live births) using data from a population-based register of CP. Children with suspected CP or who died before 1 year of age and those with CP of postneonatal origin were excluded. Prevalence of CP was 2.2 per 1,000 live births without significant change over time. Among very-low-birthweight (<1,500 g) live births, prevalence was 44.5 per 1,000 (95% confidence interval 32.3-59.8) from 1994 to 1997, with evidence of a statistically significant decline in prevalence since the mid- to late 1980s accompanied by a decrease in the severity of motor impairment and likelihood of intellectual impairment. Among moderately-low-birthweight (1,500-2,499 g) children there was weaker evidence of a peak prevalence in the late 1980s. Prevalence among normal-birthweight infants did not change significantly, but outcome in terms of severity of motor impairment and intellectual impairment improved in the 1990s. Occurrence of bilateral spasticity from 1994 to 1997 was associated with greater severity and likelihood of intellectual impairment for normal-birthweight individuals than for low- or very-low-birthweight individuals.
我们利用基于人群的脑瘫登记数据,描述了1981年至1997年北爱尔兰脑瘫(CP)按出生体重分组的患病率趋势,以及运动障碍严重程度和相关智力障碍的存在情况(n = 909;510名男性,399名女性;总人口415,936例活产)。疑似脑瘫或1岁前死亡的儿童以及新生儿期后发病的脑瘫儿童被排除在外。脑瘫的患病率为每1000例活产2.2例,随时间无显著变化。在极低出生体重(<1500克)活产儿中,1994年至1997年的患病率为每1000例44.5例(95%置信区间32.3 - 59.8),有证据表明自20世纪80年代中期至后期以来患病率有统计学显著下降,同时运动障碍严重程度和智力障碍可能性也有所降低。在中度低出生体重(1500 - 2499克)儿童中,有较弱证据表明20世纪80年代后期患病率达到峰值。正常出生体重婴儿的患病率没有显著变化,但在20世纪90年代,运动障碍严重程度和智力障碍方面的预后有所改善。1994年至1997年,正常出生体重个体双侧痉挛的发生与比低出生体重或极低出生体重个体更严重的严重程度和智力障碍可能性相关。